Experts say the direct relationship between antidepressants and blood sugar is complex and not yet fully understood.
“Research shows that different antidepressants influence glucose levels to varying degrees,” says Elizabeth A. Beverly, PhD, a professor at Ohio University in Athens and a researcher in psychosocial issues related to diabetes. “The effects on glucose depend on the specific antidepressant, dosage, duration of use, and individual factors, since everyone’s body responds differently to medications.”
“The choice of antidepressant should be individualized to the person with diabetes and their values, preferences, and needs,” says Beverly. “Encouraging healthy eating patterns, regular physical activity, glucose monitoring, adequate sleep, eliminating substance use, and behavioral healthcare can help mitigate the potential adverse effects of antidepressants on glycemia.”
Wadsworth says when someone with diabetes is selecting an antidepressant, it’s important to align the medication’s side effect profile with the patient’s symptoms.
“This ensures that any adverse effects are not only manageable but potentially beneficial,” says Wadsworth. “For example, bupropion (Wellbutrin) is a strong option for patients with type 2 diabetes, since it is weight neutral or even associated with weight loss.”
