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Can Probiotics Help the Symptoms of Crohn’s Disease?

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Can Probiotics Help the Symptoms of Crohn’s Disease?

Even though research hasn’t conclusively linked probiotics with remission in Crohn’s disease, that doesn’t mean they can’t be helpful for people with Crohn’s.

“Probiotics have been shown to be helpful for gut health in general,” says Limketkai, and Crohn’s can cause downstream digestive issues.

“When someone has Crohn’s disease, while inflammation is one factor that drives their symptoms, inflammation itself is an injury process,” he says. “And so it also then gives rise to other kinds of digestive issues” like irritable bowel syndrome (IBS), which probiotics may be able to improve.

The big takeaway, says Limketkai, is that if someone with Crohn’s is dealing with symptoms typical of a gut microbiome imbalance, it probably can’t hurt to try taking probiotics. “The risk profile is low,” he says. “It’s generally helpful for the gut microbiome. That’s why it’s [sold] over the counter,” rather than by prescription. While there is a small risk of diarrhea, that’s true for anyone starting probiotics, not just people with Crohn’s, he says.

In an analysis of 43 clinical studies involving over 5,500 people with irritable bowel syndrome, researchers found that one particular species of bacteria, known as Bacillus coagulans, was most likely to improve overall symptoms as well as abdominal pain, bloating, and straining during bowel movements. Benefits were greatest when the probiotic was taken for eight weeks.

Another analysis, involving 82 clinical studies with over 10,000 participants with irritable bowel syndrome, found with moderate certainty that strains of Escherichia bacteria helped reduce symptoms, but only with low or very low certainty that certain other strains could be helpful. On the other hand, there was no overall increase in adverse events (such as worsening of symptoms) linked to taking probiotics.

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