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Youngest brain tumor patients have significantly poorer outcomes than older pediatric patients

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A researcher at the University of Colorado Cancer Center (CU) found, through extensive research, that the youngest patients with brain tumors – those aged up to 3 months – have about half the life expectancy. five as children aged 1 to 19 years.

In a recent study published in Journal of Neuro-OncologyAdam Green, MD, a professor of oncology at the CU School of Medicine, and his researchers analyzed population data for approximately 14,500. children ages 0 to 19 identified brain tumors. They found the poorest results among younger patients.

“It’s amazing to see babies or infants with cerebral palsy, but we see them,” Green said. “We generally do not have the same treatment regimen that we do older children. We also know that infants are less likely to report their symptoms than older children.

Analysis of national cancer data

Green and his colleagues used data from the National Cancer Survey, Epidemiology, and End-of-Life (SEER) Center, a national cancer registry that covers more than a quarter of the U.S. population and represents the country’s diverse population.

The researchers extracted SEER data from childhood brain tumors and divided it into groups aged 3-0 to 3 months, 3 to 6 months, and 6 to 12 months. They compared the data in these three contexts. and cancer data in people aged 1 to 19 years.

What they found, Green said, was that “the incidence of brain tumors in infants is different. elderly patients, and this is an important research in and of itself. The most important finding we found was that infants’ life expectancy from brain tumors was worse than that of older children for almost all types of brain tumors we studied.

Further data showed that five years of life in 0 to 3 months is between 30 and 35%, while five years in 1 to 19 years reaches 70%. The five-year life expectancy at 3 to 6 months and 6 to 12 years of age is significantly lower than that of older children.

Reduce quality of life for younger people with cerebral palsy

This significant difference in five-year life expectancy “suggests that there may be confusion and anxiety in the pediatric neuro-oncology community to treat these infants or to perform surgery,” Green said. . “This may be the main reason why these children do not do this. They are also more likely to develop metastatic disease when they are diagnosed with cancer, partly because they cannot report their symptoms to so diagnosis. can be delayed. “

Small tumor patients show a different type of tumor than normal tumors in older children and are usually detected in ultrasound. Signs vary between age groups as well. Older children may present with headaches or vomiting, while “infants clearly do not report headaches, but may be chronically unwell or have rapid expansion which is one of the major risk factors.” , ”said Green. “They may not be involved in the developmental stages or they may have problems with the way their eyes move. The symptoms may be subtle and unrelated to the symptoms of brain cancer that are common in older children.”

A special challenge in the care of young psychiatric patients is that despite the fact that measures have been put in place to treat and treat pediatric psychiatric patients, providers may be slow to use on young children.

“We have antibiotics that we use for children under the age of 5, and we know they work well, but when it comes to this young patient, it can come from parents or from parents and “Medical teams think this will happen. It will be very toxic,” Green said.

The purpose is to increase awareness

Green said he hopes the immediate results of the study are to inform the public health of a five-year reduction in life expectancy for children under 1 year of age with cerebral palsy. In turn, he hopes this awareness will lead to an increased desire to use standard therapies for younger patients with mental illness.

“Overall, we still need to understand the biology of these tumors well,” Green said. “We now understand how one type of brain tumor in a baby is different from that type of brain tumor additive in an older child and we may need dedicated, special care principles for these little ones. “

Well, because a lot brain pain At the very least patients are already infected, “hopefully it will send out a local message in the pediatric community that caution is needed for this possibility,” Green said. “These tumors are not uncommon, but primary care physicians and other primary care people need to be aware that these tumors can occur in infants. The main concern is “These patients do not have the treatment to be considered safe in infants. Older children.”


A nationwide survey of 295,000 cancer patients examines differences in age and sex


Learn more:
Muriel Hart et al, A population-based study of CNS neurological disorders, treatment, and survival in prenatal and neonatal groups, Journal of Neuro-Oncology (2022). DOI: 10.1007 / s11060-022-03967-z

hint: Younger patients with tuberculosis have poorer outcomes than older pediatric patients (2022, March 18) recovered 18 March 2022 from https://medicalxpress.com/news/2022-03-youngest- brain-tumor-patients-significantly.html

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