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Why a twin blow of two COVID-19 variants may prove fatal? What difference does cvaccination make?

This is a new territory for India, but similar cases have occurred earlier in the United Kingdom, Brazil and Portugal.

Visualization of the COVID-19 virus. Image courtesy of Fusion Medical Animation

Assam’s female doctor emerged as the first case in the country COVID-19 (New Coronavirus Infection) Patients infected with two different variants of the virus at the same time.

Doctors were infected with both the alpha and delta mutants of SARS-CoV-2, even though they were completely vaccinated. ICMR’s Center for Community Health Care Research in Dibrugarh detected double infections in patients in May. One month after receiving the second dose, a woman and her husband, both doctors at the COVID Care Center, conducted the test. COVID-19 (New Coronavirus Infection) It was positive and the latter was infected with the alpha mutant.

“We collected the sample again and reconfirmed her double infection in a second test. We also performed whole-genome sequencing to confirm that both variants were infected at the same time,” he said. Senior scientist at RMRC Dr B Borkakoty. He added that a woman with mild sore throat, body pain and insomnia recovered without hospitalization.

This is a new territory for India, but similar cases have occurred earlier in the United Kingdom, Brazil and Portugal. The January detection in Brazil was the first such case in the world.

“Double infection occurs when two variants infect one person at the same time or in a very short period of time. Usually before someone infects one variant and develops immunity. , Occurs when infected with another variant within the first 2-3 days. Infection. “

According to scientists, most cases of superinfection are overlooked if gene sequencing is based solely on next-generation sequencing and variant calls are software rather than manual testing of specific gene sequencing. There is a possibility.

With this pattern COVID-19 (New Coronavirus Infection) Infection found

Brazilian researchers have found that two people are infected with two different types of mutant Brazilian strains. Coronavirus at the same time.This was believed to be the first such detection in the world COVID-19 (New Coronavirus Infection) ..

Both patients were in their thirties and were infected with the P.2 variant. Coronavirus , Also known as the B.1.1.28 strain. They again tested positive for another variant of the virus at the same time. They showed mild symptoms and did not require hospitalization.

Dr. John Macquarie, The director of the Worldwide Influenza Center at the Francis Crick Institute in London, said the two strains could encounter and exchange the genetic code-this is unlikely but worrisome.

In Belgium, a woman died COVID-19 (New Coronavirus Infection) March after signing two separate COVID variants at the same time. The patient could have been infected with two strains by two different individuals.

“Both [Alpha and Beta] The variant was endemic in Belgium when the woman became ill. ” Molecular biologist Anne Vankeerberghen said Of VRT’s Aalst OLV Hospital. “Therefore, this woman may have infected two different variants of the virus in two different people. Unfortunately, I don’t know how this infection happened.”

Why it is dangerous to infect two different variants at the same time

“The virus is an evolutionary master and constantly mutates with each cycle of replication to create new variants. Selective pressure of the host, such as the immune response, also facilitates these adaptations. Most of these mutations It does not significantly affect the virus. However, anything that benefits the virus, for example by increasing its ability to replicate or evade the immune system, is a source of concern and needs to be closely monitored. ” Written by Maitreyi Shivkumar, Senior Lecturer, Molecular Biology, De Montfort University.

Detection of multiple mutants in a person can be due to co-infection with different mutants, or due to mutations within the patient after the initial infection. The actual cause can be reached by comparing the sequences of the mutants circulating in the population with those in the patient.

A 90-year-old woman who died in a Belgian hospital in March was not vaccinated.She was positive on the test COVID-19 (New Coronavirus Infection) He then developed rapidly worsening respiratory symptoms and died five days later. Genome sequencing of samples from a woman confirmed that she was infected with two mutants.

What is the role of RNA virus?

According to Matley, “This coinfection has raised concerns that SARS-CoV-2 will acquire new mutations more rapidly. Coronavirus es can also undergo major changes in gene sequences through a process called recombination. When two viruses infect the same cell, most of the genome can be exchanged with each other to create entirely new sequences. This is a known phenomenon of RNA viruses. “

Why a twin blow of two COVID-19 variants may prove fatal? What difference does cvaccination make? Source link Why a twin blow of two COVID-19 variants may prove fatal? What difference does cvaccination make?

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