Another myth, anti-inflammatory drugs for Alzheimer’s disease may include blood transfusions altogether, which reduces the formation of amyloid plaque in the rat’s brain, according to new research from UHealth Houston.
A research team led by senior author Claudio Soto, Ph.D., professor in the Department of Neurology with McGovern Medical School at UTHealth Houston, in collaboration with first author Akihiko Urayama, Ph.D., a professor in the department a series of treatments for total blood transfusions to replace a portion of the blood from rats showing Alzheimer’s disease caused by the amyloid precursor protein with full blood from healthy mice of the same origin. The survey results are published today Molecular Biology.
“This article provides proof-of-concept for the use of commonly used medical techniques, such as plasmapheresis or blood dialysis, to‘ purify ’blood from Alzheimer’s patients, reducing the risk of stroke. toxic substances in the brain, ”said Soto, director of the George and Cynthia Mitchell Center for Alzheimer’s Disease and Mental Illness associated with the Huffington Foundation Distinguished Chair in Neurology at McGovern Medical School. circulation rather than in the brain. “
Previous studies by Soto and other UHealth Houston researchers have shown that the destruction, accumulation, and building of amyloid beta proteins in the brain play an important role in Alzheimer’s disease. Therefore, prevention and removal of lost protein components is considered an antidote.
Of course, treatment for Alzheimer’s disease has long been complicated, due to the difficulty of delivering therapeutic drugs through the blood-brain barrier. Through their recent research, Urayama, Soto, and others have found that controlling the circulating factors in Alzheimer’s disease may be the key to addressing this issue.
“Old blood vessels in the brain are considered to be the most unbearable barrier in the body,” Urayama said. “We know that the barrier is a very special moment between the brain and the system.”
After several additional blood transfusions, the researchers found that the incidence of amyloid cerebral plaques in transgenic mice of Alzheimer’s disease decreased by 40% to 80%. This reduction also resulted in improved memory function in older mice with amyloid pathology, and reduced plaque growth rate over time.
While the exact mechanism by which this blood exchange reduces amyloid pathology and improves memory is not currently known, there are several possibilities. Another possible solution is the reduction of beta amyloid proteins in the blood may help facilitate the distribution of peptide from computer to the side. Another theory is that blood transfusions somehow prevent amyloid beta flow, or prevent re-acquisition of beta amyloid, along with other potential explanations.
However, regardless of the mechanisms of action associated with blood transfusion therapy, the study suggests that the goal of Alzheimer’s treatment may lie on its side.
Prevention and treatment of reduced amyloid storage and defects in Alzheimer’s disease mice by total blood exchange, Molecular Biology (2022). DOI: 10.1038 / s41380-022-01679-4
University of Texas Health Science Center in Houston
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