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US expected to authorize mix-and-match COVID-19 booster shots

Federal regulators are expected to approve the mixing and matching of COVID-19 booster doses this week to provide flexibility as the campaign for additional shots expands. Future announcements by the Food and Drug Administration may come with booster approval. Following a shot of Modana and Johnson & Johnson and OK for a third dose of Pfizer vaccine for many Americans last month. The move was previewed on Tuesday by US health officials familiar with issues that were not allowed to speak publicly prior to the announcement. The FDA has proven that using the same brand for boosters is most effective, especially against the coronavirus, Pfizer and Modana. The agency was still finalizing the guidance for the single-shot J & J vaccine. Preliminary results from government studies on various booster combinations have found that all types of additional doses increase the level of antibodies that fight the virus, regardless of the brand that people first received. However, single-dose J & J vaccination recipients showed the most dramatic response. Antibody levels increased 76-fold and 35-fold immediately after the Moderna or Pfizer booster, respectively, compared to the 4-fold increase after the second J & J. One of the confusing decisions is the dose that Moderna recommends in combination with other brands. Moderna has applied for a booster to halve the original dose. This is enough for those who have already taken two full-strength shots. However, mixed-and-match studies use full-strength additional doses, and there is no way to know if half-dose Moderna boosters provoke a strong response to J & J recipients. Allowing mixing and matching can cause the task of getting a booster Easier for Americans and allows people who may have adversely affected the initial dose to try different shots .. Last week, the United States announced that it would allow a combination of vaccines given abroad for entry purposes. This practice was common in Canada and some European countries during the early months of the vaccination campaign. ___ Contributed by Lauran Neergaard, AP Medical Writer.

Federal regulators are expected to approve the mixing and matching of COVID-19 booster doses this week to provide flexibility as the campaign for additional shots expands.

The next announcement by the Food and Drug Administration is likely to come with the approval of Moderna and Johnson & Johnson Shot boosters, following the OK of the third dose of Pfizer vaccine to many Americans last month. The move was previewed Tuesday by US health officials familiar with issues that were not allowed to speak publicly prior to the announcement.

The FDA was expected to say that it was still preferable to use the same brand for boosters, especially for Pfizer and Modana mRNA vaccines, which have proven to be most effective against coronavirus. The agency was still finalizing the guidance for the Single Shot J & J Vaccine.

Preliminary results from government studies on various booster combinations have found that additional doses of all types increase the level of antibodies that fight the virus, regardless of the brand that people first received. However, single-dose J & J vaccination recipients showed the most dramatic response. Antibody levels increased 76-fold and 35-fold immediately after the Moderna or Pfizer booster, respectively, compared to the 4-fold increase after the second J & J. shot.

One of the confusing decisions is the dose recommended by Moderna in combination with other brands. Moderna has applied for a booster to halve the original dose. This is enough for those who have already taken two full-strength shots. However, mixed-and-match studies use full-strength additional doses, and there is no way to know if half-dose Modana boosters provoke a strong response to J & J recipients.

Allowing mixing and matching makes it easier for Americans to get boosters and allows people who may have had side effects with the initial dose to try different shots.

The United States announced last week that it would allow a combination of vaccines given abroad for entry purposes. This practice was common in Canada and some European countries during the early months of the vaccination campaign.

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Contributed by AP Medical Writer Lauran Neergaard.

US expected to authorize mix-and-match COVID-19 booster shots Source link US expected to authorize mix-and-match COVID-19 booster shots

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