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Two heart medications tied to greater heart attack risk during very hot weather

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For people with heart disease, beta blockers can improve survival and quality of life, while aspirin and other anti-platelet drugs can reduce the risk of heart attack.

But these protections can backfire during hot weather events, when heart attacks are more likely. A new study has found that among people suffering from non-fatal heart disease associated with hot weather, a significant proportion are taking these heart medications.

“Patients taking these two drugs have a higher risk,” said Kai Chen, an assistant professor in the Department of Public Health (Environmental Health) at the Yale School of Public Health and first author of the study. the investigation. “The time heat wavesThey really should be careful.”

These precautions include cooling techniques such as using air conditioning or visiting a community cooling center.

External environmental factors such as air pollution and cold weather can trigger heart attacks. Growing evidence suggests warming can do the same. However, epidemiologists are still working to find out which group of people are more prone to this extreme condition.

The methods

Using a registry, the authors looked at 2,494 cases of non-fatal heart attacks in Augsburg, Germany during the warm season (May to September) between 2001 and 2014.

In their previous study, they showed that exposure to heat or cold causes heart attacks, and they estimated that heat-related heart attacks will increase once the world warms by 2 to 3 degrees. Celsius scale.

The present study builds on this research by analyzing patients. remedy use them before the heart attack.

They analyzed the data in a way that allowed the patients to act as their own control, by comparing the temperature on the day of the heart attack and the days of the week in that month. That is, if a person had a heart attack on the third Thursday in June, the authors compared their temperature on that day with their temperature on other “control” Thursdays in June.

Both drugs involve risks

It was that users beta blockers or anti-platelet drugs were more likely to have a heart attack on the hottest days compared to control days. The use of anti-platelet drugs was associated with a 63% increase in risk and beta-blockers with a 65% increase. People taking both drugs have a 75% higher risk. Non-users of those drugs may experience heart attacks on hot days.

The study did not prove that these drugs caused heart attacks, nor did they make people more susceptible to heart attacks. Although it is possible that they have an increased risk of heat-induced heart attacks, it is also possible that patients’ heart disease explains both the prescription and the higher incidence of heart attacks during hot weather.

However, there are indications that drugs may be to blame.

When the researchers compared the younger patients (25 to 59 years) to the elderly (60 to 74 years), they found, as expected, that the younger group was healthier, with lower rates. Cardiovascular diseases. However, younger patients taking beta blockers and anti-platelet drugs are more likely to have pain-related heart attacks than older patients, even though older people have heart attacks.

Another sign that these two types of drugs can make people vulnerable: For the most part, other heart drugs have not shown a connection to heat-related heart disease. (The big one is statins. When young people take them, statins have been linked to more than three risks of a heart attack on hot days.)

“We think that some drugs may have difficulty regulating body temperature,” Chen said. He plans to try to unravel these relationships in future studies.

The results show that as climate change In addition, heart attacks can be dangerous for some people with heart disease.


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Additional information:
Kai Chen et al, Causes of heart attack by exposure to heat is altered by medication, Nature of Cardiovascular Research (2022). DOI: 10.1038/s44161-022-00102-z

hintTwo heart medications linked to increased risk of heart attack during extreme heat (2022, August 1) Retrieved August 1, 2022 from https://medicalxpress.com/news/2022-08-heart-medications-tied -greater-hot.html

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