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Targeting ‘cell clustering’ by gene deletion reduces drug resistance

Image of yeast cells and yeast cells separated after removal of the AMN1 gene. Credit: Gábor Balázsi

A recent study showing the regulation and clearance of a specific gene (AMN1) from yeast may provide a basis for a new drug-resistant approach while treating viral infections or cancer. Directed by Gábor Balázsi, Ph.D., of Stony Brook University, and published in Communication BiologyThe research center focuses on cell division that can lead to additional barriers of drug resistance in the immune system.

Drug tolerance is a major challenge to global health. Knowing how microbial the cancer cells resistance to drugs can help with the development of the best medications to treat infections. While scientists have discovered many things about the resistance mechanisms of a single virus, the problem of multiple cell pathways that are resistant to drug treatment is even more difficult. One of these many resistance mechanisms is the case where cells say together form clusters, which reduce drug uptake.

Balázsi and colleagues used high quality yeast (Saccharomyces cerevisiae) as an experimental product that demonstrates antibiotic resistance. drug resistance the cell. They remove the AMN1 gene, which is responsible for cell synthesis in this model.

“We found that after we deleted this molecule, the organism stood on its own and not formed a large nucleus,” said Balázsi, co-author and Professor Henry Laufer of Louis and the Beatrice Center for Physical & Quantitative Biology. and Professor in the Department of Biomedical Engineering at the Renaissance School of Medicine at Stony Brook University. “Furthermore, the effect of unicellular yeast is better than the control of four fungal pathogens. This suggests that disintegration of the cell membrane may result in further improved treatment.”

The research team included collaborators Lesia Guinn and Evan Lo, who tested and developed a computational system with Balázsi to quantify drug effects and make different motions of AMN1 elimination.

Overall, research suggests that AMN1 may be the next target for the treatment of fungal infections on influenza viruses.

The authors suggest that similar eradication strategies can be developed and tested to eliminate viral infections or tumors. collection of molecules.


Research has shown that evolution directs cells to return to work


Learn more:
Lesia Guinn et al, Drug-dependent developmental change describes antifungal resistance pathways in Saccharomyces cerevisiae, Communication Biology (2022). DOI: 10.1038 / s42003-022-03228-9

hint: Targeting ‘cell cramps’ through genetic elimination reduces drug resistance (2022, April 15) restored 15 April 2022 from https://medicalxpress.com/news/2022-04-cell-clustering- gene-deletion-drug.html

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