Health

Study shows that excessively high BMI is also associated with type 1 diabetes—not just the type 2

New research published in Diabetes presented at the annual meeting of the American Diabetes Association in New Orleans, Louisiana, US, showed that body mass index (BMI) in adolescents is associated with an increase in type 1 diabetes (type 1 diabetes more related to autoimmune). complexity), not just the type of species of the genus of the genus of the genus of the genus of the genus of the genus …………………………. in the type of the type of the type of the type of the type of the species ‘in the case of the type of the type of the type of the type of the type of the type of the type of the type of the type of the type of the type of the type of the type of the type of the type of the type of the type. The study was conducted by Professor Gilad Twig, Sheba Medical Center, Israel and colleagues.

It is traditionally called type 1 diabetes and childhood diabetes, occurs in children of any age and weight, although it can develop during adolescence to adulthood. However, the rapid increase diabetes growth in almost all countries today contains the highest incidence of type 2 diabetes, which is associated with an increased risk of kiba/excess weightlack of exercise and improved sitting habits.

Recently, reading a small children reported an association between BMI volume and risk to develop type 1 diabetes, but evidence at the end of adolescence is limited. This is interesting as almost 50% of cases of type 1 diabetes develop after aging (from age 18). In this new study, the authors examined the association between BMI at the end of adolescence and type 1 diabetes that occurred during adolescence.

In this nationwide survey, all young Israelis, ages 16-19, who were facing a disadvantage in compulsory military service between January 1996 and December 2016, were included for the study except if they have a history of diabetes. A total of 1.46 million young people are included. Data are combined with information on the onset of type 1 diabetes in the Israeli Diabetes Register. Weight and height were measured at the time of enrollment, and statistical analysis was used to quantify any risk factors for type 1 diabetes associated with obesity.

777 new cases of type 1 diabetes were found in 15,819,750 years of age (mean age 25 discovered). BMI was found to be associated with type 1 diabetes mellitus. In a model adjusted for age, sex and social variables, the risk of type 1 diabetes increased while BMI increased.

Compared to those young men who were categorized as having the best BMI (5)th-49th age-appropriate BMI according to the US Centers for Disease Control and Prevention), obese teens (≥95)th percentile) is twice as likely to develop type 1 diabetes, while those who are obese (85th-94th BMI percentile) has a 54% increase in the risk of type 1 diabetes. A simple risk factor (41%) appears to be in the BMI range above normal range (75th-84th BMI percent). For the entire BMI range the authors report that every 5 kg / m2 The risk of developing type 1 diabetes increases by 35%.

The authors discuss that there is a significant association between obesity and different autoimmune conditions. Another possible explanation they provide is that the levels of inflammatory adipokines and cytokines associated with obesity reduce self-resistance by enhancing the immune system leading to diabetes.

They added: “Additional factors related to obesity may contribute to bacterial overgrowth, including vitamin D deficiency, overeating, and regulating the microbiota of the gut. Given that, in our group, there is a connection between each other. cushion Obesity and type 1 diabetes even when in addition to those with a pre-existing autoimmune condition, additional factors may be associated with obesity especially type 1 diabetes. “

They stated that several biological methods have been proposed to explain the link between obesity and type 1 diabetes. cause them insulin resistance differs from different cell types in that it affects the rate of loss of beta-binding insulin-producing cells in the pancreas and ultimately leads to the appearance of clinical cancer. Based on this perception, an increase in insulin demand results beta cells additional ‘antigenic’ (autoimmune degradation), thus increasing their loss through autoimmune damage.

The authors conclude: “Our study has a significant impact on public health. The prevalence of obesity among young people is increasing globally in a alarming situation, with serious forecast for the near future. It is currently estimated that about 60% of young Americans today (over the years, 2) -19 years) will continue to be obese by the age of 35, most of them by adolescence, with half progressing to severe obesity. showed that about 1 in 8 (12.8%) of the newly diagnosed diseases of type 1 in the study were able to. in the type of the type of the type of the type of the type of the species ‘in the type of the type of the type of the type of the type of the type of the type of the type …………………………. in your type ‘if the type of species of the species of the species of the species of the species of the species of the species of the species of the species of the species of the species of the species of the species of the species of the species of the species of the species of the species of the species of the species. . -investing countries) will be more transparent. “

“Our research adds that, in terms of the health risks associated with obesity in young people, it is not just the obesity of young people that is related to the onset of adult diabetes.” if not type 2 diabetes as previously reported, but also type 1 diabetes. and obesity or the detection of general environmental factors affecting both weight and type 1. diabetes. ”


Obesity is more common in people with type 1 diabetes than previously thought


Learn more:
According to Zucker et al, Obesity in adolescence and type 1 diabetes that occurs during adolescence, Diabetes (2022). DOI: 10.1007 / s00125-022-05722-5

hintResearch shows that high BMI is associated with type 1 diabetes – not just type 2 (2022, June 5) retrieved 5 June 2022 from https://medicalxpress.com/ news / 2022-06-excessively-high-bmi-diabetes.html

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Study shows that excessively high BMI is also associated with type 1 diabetes—not just the type 2 Source link Study shows that excessively high BMI is also associated with type 1 diabetes—not just the type 2

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