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Study reveals how air pollution may increase the risk of cardiovascular disease

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Small particles of air pollution, called particulate matter, can have a variety of health effects, and exposure to high levels is a known risk factor for cardiovascular disease. In a new study led by researchers at Massachusetts General Hospital (MGH), particulate matter activates the production of inflammatory cells in the bone marrow, ultimately causing arterial inflammation, which has a detrimental effect on cardiovascular health. Has been shown to give.The survey results are published in European Heart Journal..

For retrospective studies, Cardiovascular disease Or cancer that has been imaged with MGH for a variety of medical reasons. Scientists used data from the US Environmental Protection Agency’s Air Quality Monitor closest to each participant’s address to estimate an average annual particulate matter level for each participant.

With a median follow-up of 4.1 years, 40 people experienced major cardiovascular events such as heart attack and stroke, with participants at high risk having high levels of particulate matter at their home address. It was. Their risk increased even after considering cardiovascular risk factors, socioeconomic factors, and other major confounding factors.Imaging tests to assess the condition of internal organs and tissues showed that these participants were also higher Bone marrow Activity shows increased production of inflammatory cells (a process called white blood cell production), and increased inflammation of the arteries. With additional analysis Exposure to air pollution It is a trigger that causes inflammation of the arteries.

“The pathway linking air pollution exposure to cardiovascular events through higher myeloid activity and arterial inflammation accounted for 29% of the relationship between air pollution and cardiovascular disease events,” said MGH’s Cardiovascular Imaging Fellow. One co-lead author, Shady Abohashem, MD said. “These findings suggest that air pollution exposure is an unrecognized risk factor for cardiovascular disease, a treatment that goes beyond mitigation to mitigate the cardiovascular effects of air pollution exposure. It suggests a goal. “

Co-lead author Michael Osborne, MD, a cardiologist at MGH, found that treatments targeting increased inflammation Particulate matter It can benefit patients who cannot avoid air pollution. “Importantly, most of the population surveyed had air pollution exposure well below the unhealthy threshold established by the World Health Organization. This is because the level of air pollution is really safe. It suggests that it cannot be considered, “he says.


Studies have linked a reduced risk of CV to an intensive decrease in blood pressure in patients exposed to air pollution


For more information:
Ahmed Tawakol et al, Leukocyte formation underlying the association between human air pollution and cardiovascular disease-arterial axis, European Heart Journal, 2021; ehaa982, doi.org/10.1093/eurheartj/ehaa982

Quote: Research reveals how air pollution can increase the risk of cardiovascular disease (February 4, 2021).

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Study reveals how air pollution may increase the risk of cardiovascular disease Source link Study reveals how air pollution may increase the risk of cardiovascular disease

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