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Study identifies how COVID-19 linked to Alzheimer’s disease-like cognitive impairment

PET scan of the human brain with Alzheimer’s disease.Credit: public domain

A new study led by the Cleveland Clinic has identified a mechanism by which COVID-19 causes dementia such as Alzheimer’s disease.Survey results published in Research and treatment of Alzheimer’s disease, Shows overlap with COVID-19 and common brain changes in Alzheimer’s disease, and may help inform risk management and treatment strategies for COVID-19-related cognitive impairment.

Neurological complications in COVID-19 patients and “long-distance” patients who continue to have symptoms after the infection is resolved are becoming more common, and SARS-CoV-2 (the virus that causes COVID-19) persists. Suggests that it may have a positive impact Brain functionHowever, it is still unclear how the virus causes neurological problems.

“Several studies suggest that SARS-CoV-2 is infected, Brain cells “No one else directly found evidence of the virus in the brain,” said Dr. Feixiong Cheng, an assistant staff member at the Cleveland Clinic’s Institute for Genomic Medicine and the lead author of the study. It is important to develop effective preventive and therapeutic strategies to address the outbreak of neurocognitive impairment that is expected to occur in the near future. “

In this study, researchers used artificial intelligence using existing datasets of patients with Alzheimer’s disease and COVID-19. They measured the proximity between the SARS-CoV-2 host gene / protein and those associated with several neurological disorders.Researchers also analyzed Genetic factors This has made it possible for SARS-COV-2 to infect brain tissues and cells.

Researchers have found little evidence that the virus targets the brain directly, but have found a close network relationship between the virus and genes / proteins associated with some neurological disorders, especially Alzheimer’s disease. , COVID-19 pointed out a route that may lead to AD-like dementia. To further investigate this, they investigated the potential association between COVID-19 and the neuroinflammation and cerebral microvascular injury that characterize Alzheimer’s disease.

“We found that SARS-CoV-2 infection significantly altered the markers of Alzheimer’s disease, which is associated with brain inflammation, and that certain viral entry factors are highly expressed in cells of the blood-brain barrier,” Chen said. The doctor explained. “These findings indicate that the virus may affect several genes or pathways involved in neuroinflammation. brain Microvascular damage that can lead to cognitive impairment such as Alzheimer’s disease. “

Researchers also found that individuals with the allele APOE E4 / E4, the greatest genetic risk factor for Alzheimer’s disease, reduced expression of antiviral defense genes, making these patients more susceptible to COVID-19. I have discovered that there is a possibility of doing so.

“Ultimately, we hope to pave the way for research that will lead to testable and measurable biomarkers that can identify patients at greatest risk of neurological complications from COVID-19,” Chen said. The doctor says.

Dr. Chen and his team are now using state-of-the-art network medicine and artificial intelligence technology to identify practical biomarkers and new therapeutic targets for COVID-19-related neurological problems in COVID long-distance transporters. I’m working to do it.


Researchers investigate the link between the “Alzheimer’s disease gene” and COVID-19


For more information:
Yadi Zhou et al, Network Medicine associates SARS-CoV-2 / COVID-19 infection with cerebral microvascular injury and neuroinflammation in cognitive impairment such as dementia. Research and treatment of Alzheimer’s disease (2021). DOI: 10.1186 / s13195-021-00850-3

Provided by
Cleveland Clinic

Quote: A study shows how COVID-19 is associated with cognitive deficits such as Alzheimer’s disease (2021, June 10) https://medicalxpress.com/news/2021-06-covid-linked- Identify the method obtained on June 10, 2021 from alzheimer-disease-like-cognitive.html

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