Study finds treatment that may help older people with dry eyes due to loss of sex steroid hormones

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Health benefits for people over the age of 60 include the heart and other vital organs. There are also eye-related conditions such as cataracts and glaucoma, but dry eyes are less likely to occur in the heart. Do they?

In fact, more than 70 percent of people in this age group are believed to suffer from meibomian dementia, which is more common. dry eyes.

A new study led by researchers at the University of Kyoto has reported that the loss of sex steroid hormones produced by the enzyme 3-hydroxyl-steroid dehydrogenase, or 3-HSD, causes the condition, but can treat it with nicotinamidemononucleotide, or NMN, which is a non-steroidal agent.

“Meibomian glands are found in the eyelids and play a role in the production of oil that closes the eyes. Without this oil, tears flow,” said project manager Masao Doi.

Despite the high incidence of meibomian virus, it does not appear to be life-threatening. However, unhealthy conditions can cause serious eye damage if left untreated.

There is currently no cure for meibomian disease because the mechanisms underlying it are still unknown.

As we get older, our own hormone production it is declining. The most well-known examples are sex hormones, such as testosterone and estrogen, which are clearly related to age-related factors of meibomian disease.

Normally, hormones are produced by the endocrine organs and then enter the bloodstream where they travel to regulate other parts of the body. However, using mutant rats, studies have shown that instead of this endocrine system, the meibomian gland relies on a recently discovered intracrine system in which the hormone acts in the tissue where it is synthesized.

“Of course, intracrine stress 3-HSD enzyme activity In rats detected they cause glandular atrophy, which further leads to illness, ”Doi concludes.

The main interest of the 3-HSD group lies in its circadian rhythm, which is responsible for hundreds of motor behaviors such as sleep, menstruation, and secretory hormones. Further research on these circadian rhythms is expected to provide additional clues on the management of 3-HSD condition.

Doi added, “We have found that the enzymatic activity of 3-HSD peaks in mice as they sleep. This observation indicates when drug administration is important.”

The oscillating activity of 3-HSD is highly correlated with the 3-HSD cofactor nicotinamide adenine dinucleotide, or NAD, which is a coenzyme found in all cells and is marketed as an over-the-counter supplement. It also receives attention as a compound in drug synthesis for its ability to activate or inhibit hormone-producing enzymes including 3-HSD.

Confirming this point, studies show that the use of nicotinamide mononucleotide, or NMN, a precursor of NAD, increases the amount of NAD required to reactivate 3-HSD functions. Periodic addition of NMN to the meibomian gland of rat mice reduces atrophy of the meibomian gland, effectively reducing dryness in the eyes.

Although steroids, such as testosterone, usually have unintended side effects, Doi said, “Our research shows that it is possible to avoid this problem not only with home remedies but also with an unhealthy agent, such as su NMN. ”

The immune response is probably the culprit in the eyelid condition that causes dry eye

Learn more:
Lena Sasaki et al, Intracrine activity that includes NAD-dependent circadian steroidogenic activity controls age-related meibomian gland dysfunction, Nature Aging (2022). DOI: 10.1038 / s43587-021-00167-8

Its formation
Kyoto University

hint: Research has found a drug that can help older people with dry eye due to loss of sex hormones (2022, March 10) restored March 10, 2022 from older-people- eyes-all.html

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