Study finds important differences in monkeypox symptoms between current and previous outbreaks

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Another published study BMJ today found significant differences in symptoms between current smallpox outbreaks and past outbreaks in endemic areas.

The findings are based on 197 confirmed cases of meningitis at a London-based disease center between May and July 2022.

Some of them are common symptoms have appeared, including rectal pain and penile swelling (edema), is different from those described in the previous epidemic.

Therefore, the researchers recommend that doctors should consider meningitis in patients who show these symptoms. And they said those confirmed to be infected with monkeypox who have extensive penile lesions or severe genital pain “should be considered for further evaluation or patient care.”

According to government data, as of 18 July 2022, there have been 2,137 confirmed cases of meningitis in the UK. Of these, 2,050 were in England and almost a third (73%) were in London.

All 197 participants in this study were men (average age 38), of whom 196 identified as gay, bisexual, or other men who have sex with men.

All patients presented lesions on the skin or mucosal membranes, usually on the genitals or in the perianal area.

The majority (86%) of patients reported systemic illness (it affects the whole body). The most common systemic symptoms were fever (62%), swollen lymph nodes (58%), and muscle aches and pains (32%).

And it is different from the usual reports that show that the symptoms are already present in the skin lesions, 38% of the patients continued to show symptoms after the presentation of mucocutaneous symptoms, while 14% presented the lesions without structural features.

A total of 71 patients reported rectal pain, 33 throat pain, and 31 penile edema, while 27 had oral lesions, 22 had a single lesion, and 9 had swollen tonsils.

The authors note that isolated lesions and swollen tonsils are not previously known features of monkeypox infection, and may be mistaken for other conditions.

Over a third (36%) of the participants also had HIV and 32% of those diagnosed with a sexually transmitted disease were sexually transmitted.

Overall, 20 (10%) of the participants were admitted to the hospital for treatment of symptoms, usually pain and swelling of the penis. However, no deaths were reported and no patients required special care in the hospital.

Only one participant had recently traveled to an endemic area, confirming the continued spread of the disease in the UK, and a quarter of patients knew of contact with someone with confirmed meningitis which increases the possibility of transmission of the disease by people who have no or little.

The authors acknowledge some limitations, such as the observational nature of the findings, the possibility of changes in clinical records, and the fact that the data are limited to a single institution.

However, they say these findings confirm the continued spread of unprecedented news in the community meningitis A virus that has been seen in the UK and many other countries where there is no connection between gay, bisexual, and other men who have sex with men.

The authors write, “Understanding these findings will have major implications for contact tracing, public health recommendations, and ongoing infection control and isolation measures.”

They call for continued research to inform infection control and quarantine policies and to guide the development of new diagnostics, treatments, and preventive measures.

The symptoms of monkeypox in patients attending London hospitals are different from previous outbreaks

Additional information:
Clinical features and novel presentation of human meningitis in central London during the 2022 outbreak: a comparative case series, BMJ (2022). DOI: 10.1136/bmj-2022-072410

The one who gave
British Medical Journal

hintResearch finds significant differences in meningitis symptoms between current and past outbreaks (2022, July 28) Retrieved July 28, 2022 from -differences-monkeypox-symptoms-current.html

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Study finds important differences in monkeypox symptoms between current and previous outbreaks Source link Study finds important differences in monkeypox symptoms between current and previous outbreaks

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