New research from the Healthy Nevada Project® has found associations between genetics, obesity, and childhood disability, combining factors that influence social health, genetics, and disease. The study, published this week in Next in Geneticsfound that participants with specific genetic predispositions and those with childhood traumas were more likely to suffer from adulthood.
In 2016, the Center for Desert Research (DRI) and Renown Health launched the Healthy Nevada Project®, the first community-based, public health study, which now has over 60,000 participants. The project is a partnership with a unique genetic company, Helix, and combines biological, environmental, social, and clinical data to address individual and community health needs with the aim of improving health across the state and country.
The new study focuses on Acute Childhood Disorders (ACEs), which are traumatic and insecure that children endure under the age of 18. More than 16,000 participants in the Healthy Nevada Project® responded to a health survey brains, and more than 65 percent of these individuals. report at least one ACE event. These 16,000 participants were included with their genetic makeup, and Body Mass Index (BMI).
According to the study group, study participants who received one or more ACE types were 1.5 times more likely to be obese adults. Participants who experienced four or more ACEs were twice as likely to be obese.
“Understanding that Physical Therapists, such as abuse, poverty, malnutrition, and poor relationships with primary caregivers increases a person’s risk for obesity but also interacting with your genes is key to understanding how we can provide and intervene in the past, helping to reduce health disparities, and create Nevada Health for all, ”said Tony Slonim, MD, DrPH, President & CEO of Renown Health. Slonim, President of Reno, NV-based Renown Health, is the first four-certified physician in the United States with certifications in critical care, pediatrics, pediatrics, and pediatrics. and holds a Doctorate in Public Health.
“Our study shows a continuous increase in BMI for each ACE that a person receives, indicating a strong and significant relationship between the numbers. traumatic events of children the upper kiba“says lead author Karen Schlauch, Ph.D., of DRI.” Most importantly, BMI participants are more responsive to ACE events when combined with other mutations in multiple genes , one of which is associated with schizophrenia. ”
“We know that genetics affect diseases in the gut Nevada Health Center®, and now we understand that ACEs also affect disease, “said lead researcher Joseph Grzymski, Ph.D., of DRI and Renown Health. and many more. In a particular health community, it is more likely to have serious health consequences than any other variant alone. More than ever, this new project emphasizes its importance to the general population organic matter study to consider the impact of social factors on health outcomes. ”
The research team believes that it is important for clinicians to understand the strong impact that negative factors such as ACEs can have on the health of children and adults. The researchers hope the information from this study will encourage doctors and nurses to conduct simple tests for ACE and to consider the patient’s social status and history with genetics when developing treatment plans for improved health. patience.
According to the 2019 Youth Behavior Risk Survey (YRBS), 25.6 percent of Washoe County youth are overweight or obese. Obesity is a major concern for the health of children and young people. According to the Centers for Disease Control and Prevention, obese children and adolescents are more likely to be obese since they are adults.
“Obese children and adolescents are at increased risk for multiple health problems during adolescence, which can be more severe as adults,” said Max J. Coppes, MD, PhD, MBA, FAAP, Nell J Redfield Chair of Pediatrics at the University of Nevada Reno School of Medicine, Physician at the General Pediatric General Hospital. “Obese and overweight teens are at increased risk for heart disease, such as high blood pressure, high cholesterol, and type 2 diabetes. more and more, it improves the quality of life for a lifetime. ”
“We would like to thank all the participants of the Healthy Nevada Project® who provided the information to do our work,” said Robert Read, MS, of DRI. “Our research shows that it is not only genes that cause diseases, but also our environment and lifestyle factors interact with our genes to influence our health through the ways we first understand it.”
Karen A. Schlauch et al, ACE Impact on BMI: Biological Survey of BMI, Next in Genetics (2022). DOI: 10.3389 / fgene.2022.816660
Center for Desertification Studies
hint: Research Finds Child Injuries and Organisms Related to Increasing the Risk of Obesity (2022, March 9) Retrieved 9 March 2022 from https://medicalxpress.com/news/2022-03-childhood-trauma-genetics -linked-obesity.html
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Study finds childhood trauma and genetics linked to increased obesity risk Source link Study finds childhood trauma and genetics linked to increased obesity risk