Study examines the effects of COVID-19 on human kidney cells

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Researchers studied human kidney cells in the lab to investigate the effects of COVID-19 on kidney health.The findings will be displayed in the next issue of JASN..

Many people who develop COVID-19 also experience it kidney There is damage, but it is unclear whether this is the direct result of a viral infection, the result of another condition, or the body’s reaction to the infection. A team led by Benjamin Dekel, MD, Ph.D. to investigate. (Israel Sheva Medical Center) Cultivation Human kidney cells It was placed in a laboratory dish and infected with the virus that causes COVID-19.

Researchers have discovered that the virus that causes COVID-19 can invade, infect, and replicate the kidneys of adult humans. cell, This usually did not cause cell death.Prior to infection, cells contained high levels of interferon signaling molecules and infection was Inflammatory reaction It increased these molecules. In contrast, infection of kidney cells lacking such molecules results in cell death, suggesting a protective effect.

The cells of these experiments grew as a three-dimensional spheroid that mimics a healthy kidney or as a two-dimensional layer that mimics the cells of an acutely injured kidney.Cells that mimic acutely injured kidneys are susceptible to infection and additional damage, but not Cell death..

“Data show that the virus is unlikely to be the leading cause of acute kidney injury seen in COVID-19 patients. This means that if for any reason such damage occurs in the kidneys, the virus Therefore, if we can limit the general scenario of acute kidney injury in the first place, it may minimize the potential damage caused by the virus. There may be, “explained Dr. Deckel.

Immune response after COVID-19 vaccination in kidney transplant and dialysis patients

For more information:
“Human renal spheroids and monolayers provide insight into SARS-CoV-2 renal interactions.” JASN, DOI: 10.1681 / ASN.2020111546

Quote: In the survey, human kidney cells obtained on June 10, 2021 from https: // (June 10, 2021) ) Is being investigated for the effect of COVID-19.

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Study examines the effects of COVID-19 on human kidney cells Source link Study examines the effects of COVID-19 on human kidney cells

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