Some blood pressure medicine may decrease the aneurysm rupture risk for people with high blood pressure

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A study of more than 3,000 people with high blood pressure and cerebral aneurysms found that using anti-RAAS, a type of antihypertensive drug, reduced the risk of aneurysm recurrence by 18%, according to a new study. study published today. if High blood pressure newspaper.

Aneurysm is a swelling or injury to a nerve wall. When this happens in the nerves in the brain, it is called the intracranial aneurysm. If intracranial aneurysm ruptures, it ruptures blood around the brain and cuts oxygen to the affected area, which can lead to a blood pressure, fainting and death. These strokes make up 3-5% of all strokes, but have a higher percentage of illnesses and deaths than other types of strokes. Every year, almost 30,000 adults in the United States they have intracranial aneurysms that explode, according to the Centers for Disease Control and Prevention. In addition, stroke is a major cause of disability in the United States.

The renin-angiotensin-aldosterone system of the body (RAAS) includes the active hormones high blood pressureand dysregulation of RAAS may lead to progression high blood pressure. Two types of RAAS have been shown to be involved in the development of abdominal pain, and previous research has found that dysregulation of RAAS may contribute to the degeneration of aneurysm. RAAS inhibitors, drugs that block the effects of RAAS, are used to treat high blood pressure pressure.

“Nearly half of patients with intracranial aneurysms have high blood pressure, which can lead to inflammation of the arteries and increase the risk of aneurysm rupture,” said lead author Qinghai Huang, MD, Ph.D., professor. of neurosurgery at Changhai Hospital, II. University of Medical Sciences in Shanghai, China. “Considering that one-third of patients with ruptured aneurysms die and one-third are dependent on daily activities, there is a need to identify risk factors to prevent recurrence. aneurysm. “

This in-depth study analyzed data collected from 2016 to 2021 at 20 health centers in different parts of China, collected before and after the explosion, to evaluate the group using anti-RAAS and other anti-hypertensive drugs, including beta-blockers. and diuretics, on the risk of aneurysm rupture.

More than 3,000 adults with hypertension and intracranial aneurysms are involved. The sample size was one-third male and two-thirds female, with an average age of 61 years. care (blood pressure, expressed as 140/90 or above, with the use of antihypertensive drugs), and is determined by the measured blood pressure. at the same time, three months before they were hospitalized for anerysm.

The study found that 32% of participants who took RAAS inhibitors experienced a reduction in intracranial aneurysm, compared with 67% of those who used RAAS inhibitors.

“We were surprised to find that even in people with high blood pressure, those who took RAAS inhibitors still had a lower risk than those who took RAAS inhibitors. Our study shows that the use of antiretroviral drugs Proper antihypertensive to achieve normal blood pressure. can significantly reduce the risk of developing aneurysm, “Huang said.

“Based on these data, we estimate that approximately 18% of ruptured aneurysms can be prevented if all patients with high blood pressure and intracranial aneurysms are enrolled with RAAS inhibitors. prevent RAAS, these findings may be inhibitors. It also helps doctors improve treatment to help patients with high blood pressure to prevent aneurysm outbreaks. “

Using a multivariate regression model, the researchers calculated that the risk of aneurysm in women is 1.8 times higher than the risk of men, and the following factors increase the risk of aneurysm:

  • low blood pressure;
  • clear to smoke; same to you
  • type 2 diabetes without treatment.

“These findings confirm previous research that suggests that – in addition to controlling high blood pressure – smoking cessation and treatment for type 2 diabetes may help reduce the risk of developing aneurysm. Huang said. “However, more research is needed to understand how RAAS inhibitors are involved in intracranial prevention. anerysm breaking in adults with high blood pressure. “

The authors note that the limitations include the nature of the study, the potential for conflict, that hypertension is defined as high blood pressure of 140/90, rather than 130/80, that the actual blood pressure of participants is not taken into account and that the duration and severity of RAAS inhibitors are not recorded in the data.

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Learn more:
Effects of Renin-Angiotensin-Aldosterone System Inhibitors on the Risk of Rup in Anemia With Intracranial Aneurysms, High blood pressure (2022). DOI: 10.1161 / HYPERTENSIONAHA.122.18970

hintSome high blood pressure medications may reduce the risk of aneurysm outbreaks in people with high blood pressure (2022, June 3) Retrieved 3 June 2022 from -decrease- anerysm.html

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Some blood pressure medicine may decrease the aneurysm rupture risk for people with high blood pressure Source link Some blood pressure medicine may decrease the aneurysm rupture risk for people with high blood pressure

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