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Researching the mystery of consciousness after brain injury

Researchers at Stony Brook have identified the role of the thalamus as a therapeutic target for patients with cerebral palsy. Credit: Sima Mofakham

Depression after a traumatic brain injury (TBI) has always been a mystery to scientists and is not easy to predict. A recent study published by researchers at the Department of Neurosurgery at the Renaissance School of Medicine at Stony Brook University found that by using technology to monitor brain function after TBI, scientists can predict which will “wake up” after. TBI and what the brain navigates to target for the possibility of resolving cognitive conflicts.

Humans have the ability to perform infinite variety of behaviors, so human perception is temporary conduct impossible. Through brain reading wound patients in detail, co-authored by Sima Mofakham, Ph.D., Assistant Professor in the Department of Surgery and Electrical Engineering, and Charles Mikell, MD, Assistant Professor in the Department of Neurosurgery, identified brain departments. required for unpredictable behaviors, which they consider to be the most common characteristic of human civilization. Their research included colleagues in the joint Neurosurgery Laboratory, as well as partners in the country.

“After a brain injury, the mentally retarded and the mentally retarded do not do much, they do not participate in the behavior of the target, and their behavior is highly predictable,” said Dr. Mikell.

Summarizing the link between the study and this situation with TBI patients, Dr. Mofakham stated: By studying. patients with cerebral palsy in this state, we find brain circle required for unpredictable behaviors. In particular, we found that an injury to a part of the brain called the thalamus causes a ‘change of attraction’ in the brain. ‘Attractions’ are ways of describing repetitive activities, in which the brain has difficulty escaping, such as trying to escape from a hurricane. The thalamus is a large part of the brain that regulates function in certain parts of the brain.

“For cortical networks, stimuli limit the availability of different brain states, and therefore behaviors. We found reliable thalamocortical joints may support behavioral and electrophysiological impairments associated with cognition.”

First paper, published in Communication Biologywhich includes the use of electronic devices implanted in the brain to check brain capacity in patients who have recovered while recovering. brain injury. This use of implanted implant devices (depth) made this first study of its kind and opened a new window to post-traumatic stress disorder in patients. They identified five patients in a unique study that combined brainwave recording with brain imaging in an attempt to understand how thalamus injury affects cortical function.

The main thing they discovered was the insertion of the thalamus formation of the cortical groups needed to restore cognitive function and civilization. This observation supports the notion that the thalamic entry into the cortex allows for a rich supply of cortical energy associated with consciousness.

In a paper published on Advances in Neurobiology, Drs. Mofakham and Mikell and their colleagues, found in a group of patients (n = 15) that the number of cortical states was limited, and brain function could be predicted in patients with injuries to the thalamus and projection to the cortex. They found that the reversal of thalamic induction results in an abnormal environment with a limited number of regions, leading to specific behaviors.

They write that “the results are in line with the new concept of the thalamus: the thalamus is not only a media center, but it can control the adaptive system distributed internally and between cortical networks to support cognitive function “Many reports support it.

Research published in Frontiers in Neurology suggests that people with thalamic insufficiency and injuries to the central nervous system, are less likely to recover cognitive content. This study included a study of 25 patients after severe TBI. They investigated whether the integrity of the thalamo-prefrontal cortex, which was assessed by a diffuse image, was related to the return of normal behaviors.

Some patients recovered, but others did not recover, and more than half returned to a state where they could follow orders or engage in other meaningful activities. All the researchers’ data from their imaging and clinical trials support that an improved prefrontal cortex is important for a return to appropriate behaviors.

Overall, the researchers provided a way to better understand the issues brain and recovery after TBI.


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Learn more:
Sima Mofakham et al, Electrocorticography shows thalamic power of cortical stimuli resulting in brain injury. Communication Biology (2021). DOI: 10.1038 / s42003-021-02738-2

Sima Mofakham et al, Thalamocortical Traumatic Injury as a result of traumatic brain injury results in increased sensitivity to cortical networks, Advances in Neurobiology (2022). DOI: 10.1016 / j.pneurobio.2022.102215

Megan E. Cosgrove et al, Thalamo-Prefrontal Syndrome Equivalent to First Instruction-Following Traumatic Brain Injury, Frontiers in Neurology (2022). DOI: 10.3389 / fneur.2022.826266

hintThe Secret Knowledge After Brain Injury (2022, March 31) Retrieved March 31, 2022 from https://medicalxpress.com/news/2022-03-mystery-consciousness-brain-injury.html

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