Researchers uncover new details behind inflammation that promotes heart disease

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Hypercholesterolemia and inflammation are the major causes of heart disease, and the accumulation of inflamed lipids can block the blood supply through the coronary arteries and cause a heart attack. A team led by scientists at Massachusetts General Hospital (MGH) recently studied aspects related to cell production, as white blood cells, which normally prevent infection, cause inflammation in these situations. Group insights Nature Cardiovascular Research, May lead to new strategies for protecting cardiovascular health.

“Patients with heart disease have higher numbers of leukocytes,” said Matthias Narendorf, a researcher at MGH’s Center for Systems Biology and a senior author of radiology at Harvard Medical School. “Many of these cells are found in plaque, an accumulation of fat, cholesterol and other substances in the blood vessels, where they arrive after birth. Bone marrow And it moves through the bloodstream. However, it is not clear what leads to increased bone marrow excretion. “

Through experiments performed on human bone marrow and mice, Narendorf and his colleagues have been found to have hypertension, atherosclerosis, and heart attack Each can cause a change in numbers Blood vessels In the bone marrow. These features of cardiovascular disease also altered the structure and function of bone marrow vessels and affected the release of factors that regulate leukocyte production and migration.

“As a result, more White blood cells Narendorf said, “This increase, called leukocytosis, promotes inflammation everywhere, including the arteries and heart. This study can find out how to reduce the production of white blood cells to normal levels. Cool the raised plaque somewhere on your body. “

Co-authors include MGH’s David Rohde, MD, Katrien Vandoorne, and Ph.D. others.

“This study provides strong evidence that cardiovascular disease affects the myeloid vascular system and, as a result, the activity of blood stem cells,” said the Department of Cardiovascular Science, National Institute of Cardiopulmonary Blood Research. Said Dr. Michel Olive, Program Officer of. Part of the National Institutes of Health. “This study sheds new light on the important role played by the vascular bone marrow niche and how inflammation develops. Heart disease, The main cause of death. ”

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For more information:
Matthias Nahrendorf, Bone Marrow Endothelial Dysfunction Promotes Bone Marrow Cell Proliferation in Cardiovascular Disease, Nature Cardiovascular Research (2021). DOI: 10.1038 / s44161-021-00002-8..

Quote: Researchers reported heart disease (December 23, 2021) obtained from https: // on December 23, 2021. Reveals new details behind promoting inflammation

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Researchers uncover new details behind inflammation that promotes heart disease Source link Researchers uncover new details behind inflammation that promotes heart disease

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