Health

Researchers make a novel discovery in age-related macular degeneration

The structure reflects the activity (s) of the adhesive molecules, cytokines, and chemokines. Credit: Aging-US.com

A new research paper has been published Tsufa (Tsufa-US)entitled “The Impact of Humane G (HNG) on Inflammation in the Age of Macular Degeneration (AMD).”

Inflammatory processes lead to my progression Macular degeneration related to age (AMD) disease – the leading cause of loss of vision in the United States.

In this new antiquity study, researchers from the University of California Irvine and the University of Southern California compared protein Inflammatory signaling pathways in normal and AMD retinal pigment epithelial (RPE) transmitochondrial cybrid cells and investigating the effect of treatment with the effective Humanin G.

Humene G (HNG) is a mitochondrial peptide that is cytoprotective in AMD and can protect against mitochondrial and cellular stress damaged by AMD mitochondria.

“The purpose of this study is to test our hypothesis that protein levels associated with inflammation are increased in AMD and treatment with HNG results in a decrease in protein levels.”

Human G protein levels in the plasma of AMD patients were measured in routine subjects using the ELISA test. Humane G was added to AMD and custom cybrids obtained from AMD patients in clinical and routine subjects. Lysates were extracted from untreated AMD and HNG and conventional cybrids, and the Multiplex Luminex XMAP test was used to measure inflammatory protein levels.

The researchers found that there were significant differences in inflammatory proteins between normal and plasma samples of AMD. Compared with plasma products, AMD plasma exhibits higher protein levels of inflammatory markers. However, the plasma levels of endogenous Human protein were less than 36.58% in AMD patients compared to those in normal subjects. After treatment with Humanin G, the researchers observed a decrease in protein levels of inflammatory markers elevated in the cybrid cells of the AMD RPE transmitochondrial.

“Finally, we present a new study that: a) shows a decrease in Humanin protein levels in the plasma of AMD vs. normal plasma; b) suggest the role and symptoms of inflammation in AMD patients, and and c) shows positive effects of Humanin G to reduce inflammation. in AMD. “

To determine the associations, this is the first study reported to reduce Humanin protein levels in AMD patients, thus confirming the important role of Humanin in the management of tissue homeostasis and routine function in the eye.

“Our study is informative and may contribute to the development of therapeutic tools to reduce inflammation to reduce the incidence of AMD,” the researchers concluded.


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Learn more:
Sonali Nashine et al, The Impact of Humane G (HNG) on Inflammation in Macular Degeneration (AMD), antiquity (2022). DOI: 10.18632 / old.204074

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hint: Researchers have conducted a new study on macular degeneration related to age (2022, May 31) retrieved May 31, 2022 from https://medicalxpress.com/news/2022-05-discovery- age-related-macular-degeneration.html

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Researchers make a novel discovery in age-related macular degeneration Source link Researchers make a novel discovery in age-related macular degeneration

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