Health

Researchers identify promising treatment path

Mouse segment seen using a bright light meter. Credit: Institut Pasteur / Mariana Alonso and Pierre-Marie Lledo

The brain can detect and regulate local or systemic inflammation using two networks. First, humorously, it uses a specific brain system that allows inflammatory mediators to enter the brain. Second, nerves, consist of nerves whose sensory neurons transmit inflammatory signals detected at the local level.

The bad nerve so it is used to identify receptors to detect digestive or lung inflammation. Especially brain features and networks predict and combine these humorous and neurological messages and formulate a theoretical response that includes neuroendocrine, neurovegetative and behavioral factors. These repair processes are controlled by the hypothalamus and the hypophysis — an autonomic nervous system and a limbic system. Neuroendocrine activation is characterized by the release of cortisol, a major stress hormone. The autonomic response involves a combination of activation of the sympathetic and vagal systems, with the latter believed to trigger a local inflammatory response. Behavioral changes affect mood, attention, sleep and appetite. The goal of general response is to control inflammation to maintain body integrity, or homeostasis. But in some cases, it can be unbalanced and can lead to immunity and / or mental illness.

Severe infection known as sepsis is the most common cause of this safety strategy and inflammatory stress. Sepsis is the leading cause of death in the world and represents a major public health challenge. What makes the situation worse is that sepsis is also associated with chronic mental illnesses such as anxiety, depression and post-traumatic stress disorder. These conditions greatly increase the risk of suicide and have a lasting impact on the individual, social and mental health of patients. “So far no vaccine has been shown to be effective, possibly due to a lack of understanding of the physiology of these diseases, especially of the nervous systems involved in their early stages,” said Professor Tarek Sharshar, Head of the Department. Neurology and Sainte-Anne. .

In a test case published in the journal Kwakwalwaa team of scientists from the Institut Pasteur (Perception and Memory Laboratory) and doctors from the Paris Psychiatry and Neurosciences University Hospital Group (GHU) used pharmacogenetic technology to identify a specific neural circuit consisting of central medial medial. amygdala and the central bed of the stria terminalis. Activating this circle in the first few hours of sepsis causes a stressful situation two weeks after infection. This condition observed in mice mimics post-traumatic stress disorder seen in patients recovering from sepsis.

“This study paves the way for new therapeutic strategies for sepsis: We note that the administration of an anti-seizure agent reduces the risk of developing sepsis,” said Professor Pierre-Marie Lledo, Institut Pasteur and CNRS. This effect is thought to be related to a decrease in the activation of the vagal afferent joint.

This study is particularly interesting because it explores the whole circle of sacrifices for the after-sepsis concerns about the potential of pharmacological treatment. The latter will be tested soon in a randomized controlled trial in several centers. By describing the link between inflammatory neuroinflammation and psychiatric disorders, this study correlated the current status of COVID-19 with long-term COVID.


Cystic fibrosis prolongs the life of sepsis in mice


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Received OUP script, Kwakwalwa (2021). DOI: 10.1093 / brain / awab475

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Kwakwalwa

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hintWhen a serious infection results in a long-term allergic reaction: Researchers have found an interesting treatment method (2022, April 19) that was recovered 19 April 2022 from https://medicalxpress.com/ news / 2022-04-severe-infection-long-term-mood-health.html

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