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Researchers find two FDA-approved drugs that curb symptoms of Alzheimer’s disease

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The two most commonly used antipsychotics show signs of improving Alzheimer’s disease symptoms including increased comprehension, according to a study by researchers at the University of Colorado Anschutz Medical Campus.

“People who take these medications have a better understanding and have actually improved clinical diagnosis“says lead author Huntington Potter, Ph.D., professor of physiology at the University of Colorado School of Medicine and director of CU Alzheimer’s and Cognition Center.” Compared to those who did not take these drugs, have returned from Alzheimer’s disease to cognitive impairment or from severe insanity to normal. “

The study is published today in the journal Alzheimer’s Research & Therapy.

The drugs, imipramine antidepressant and antipsychotic olanzapine, have already been approved by the Food and Drug Administration. And since depression and anxiety are common in those with Alzheimer’s disease (AD), many patients are taking certain medications for these problems, providing more attention to scientists to evaluate the impact.

The CU Anschutz research team, led by Noah Johnson, Ph.D., is looking for drugs that block the effects of apolipoprotein E4 protein or APOE4, which is synthesized by a variety of genes that, when exhausted, pose the greatest risk grow to develop late. – Alzheimer’s disease.

“We took a very specific approach by attacking APOE4 because of its routine remedy The target, amyloid-beta and tau, do not provide effective treatment for people with AD despite years of activity, ”Johnson said.

The researchers examined 595 compounds in the drug library from the National Institutes of Health and identified several compounds that inhibit the effect of APOE4 specifically on the formation of amyloid Alzheimer.

“We then looked into the National Alzheimer’s Center (NACC) and asked what happened when a medication was prescribed for normal symptoms but it happened to Alzheimer’s disease,” Potter said.

It was then that they discovered this psychiatrists with AD using imipramine and olanzapine showed significant improvement in AD symptoms.

“The only thing these drugs do with them is to block the potential effect of APOE4 on the formation of amyloids in the brain,” Potter said, referring to proteins that cause inflammation and disrupt cell function in AD.

The results were surprising.

“Our study shows that, compared to the control group, subjects taking imipramine or olanzapine improved perception and diagnosis, which is the direct clinical outcome of the disorder,” the study said. “In particular, in our clinical trials, we found that imipramine and olanzapine inhibited apoE4-catalyzed Aβ fibrillization.amyloid beta), while none of the other antidepressants or antibiotics have been reported for use in NACC data that have a similar function and none have shown any benefit for AD patients. “

Potter warns that the research is backward, meaning they did the research while analyzing the data collected for a specific purpose. The next step, he said, is to test imipramine, which has fewer side effects than olanzapine, on rodent formulations and if clinical trials are successful.

“Most folk remedies that show any benefit to AD patients are probably one or two or three,” Potter said. “So this is an exciting development.”


Researchers are debating the type of APOE4, the most important risk factor for Alzheimer’s disease


Learn more:
Noah R. Johnson et al, Imipramine and olanzapine block apoE4-catalyzed polymerization of Aβ and show evidence of improving Alzheimer’s disease, Alzheimer’s Research & Therapy (2022). DOI: 10.1186 / s13195-022-01020-9

hintResearchers have identified two FDA-approved drugs that treat the symptoms of Alzheimer’s disease (2022, June 29) and were recovered 29 June 2022 from https://medicalxpress.com/news/2022-06-fda-approved -drugs-curb-symptoms-alzheimer .html

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Researchers find two FDA-approved drugs that curb symptoms of Alzheimer’s disease Source link Researchers find two FDA-approved drugs that curb symptoms of Alzheimer’s disease

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