Researchers develop new generation NIR-II dyes for biomedical imaging

Nature communication (2022). DOI: 10.1038/s41467-022-31521-y” width=”800″ height=”530″/>

Development of a new generation of NIR-II DAD dyes through receiver engineering techniques. Previous NIR-II DAD dyes used BBT and PTQ as electron acceptors; b DAD NIR-II fluorophore structure of this project based on the TQT receptor. Credit: Nature communication (2022). DOI: 10.1038/s41467-022-31521-y

Near infrared window-II (NIR-II, 1000-1700 nm) fluorescence imaging has recently emerged as a front-runner in molecular imaging and translational research.

Donor-acceptor-donor (DAD) type fluorophores generally exhibit good biocompatibility, and optical properties, which have been widely used in biological imaging. However, most research has focused on developing the donor side and not much attention has been paid to the recipient side.

In a study published in Nature communicationresearchers led by Cheng Zhen and Chen Hao from the Molecular Imaging Center of the Shanghai Institute of Materia Medica (SIMM) of the Chinese Academy of Sciences have reported a novel water-soluble NIR-II dye, FT-TQT, for biomedical imaging applications. which is based on a new electron acceptor, 6,7-di(thiophen-2-yl)-[1,2,5] thiadiazolo[3,4-g] quinoxaline (TQT).

Compared to traditional electron acceptors, benzobisthiadiazole (BBT) and 6,7-diphenyl-[1,2,5] thiadiazolo[3,4-g]quinoxaline (PTQ), TQT shows higher stability in alkaline conditions than BBT and 50nm longer wavelength in the absorption spectrum than PTQ.

Furthermore, TQT-based DAD dyes show high stability under reactive oxygen species/ nitrogen species (ROS/RNS), metal ionsactive biomolecules, and different alkaline conditions.

In addition, the TQT-based DAD dye, FT-TQT, shows real-time brain activity and brain activity. NIR-II A glowing image has a strong control of vascular collapse after treatment with combretastatin A4 phosphate (CA4P).

This study provides an interesting molecular design strategy for the development of new NIR-II fluorophores. Also, it provides a important tool to monitor and evaluate the treatment of diseases related to blood vessels.

Cocrystal engineering: A multi-material design technique

Additional information:
Aiyan Ji et al, Acceptor engineering for NIR-II dyes with high photochemical and biomedical activity, Nature communication (2022). DOI: 10.1038/s41467-022-31521-y

hint: Researchers develop new NIR-II dyes for biomedical research (2022, August 5) retrieved August 5, 2022 from imaging.html

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