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Research team develops new screening assay for drugs targeting prostate cancer

Prostate cancer cells. Credit: NIH Photo Gallery

A new cost-effective study has been created to identify androgen receptor blockers, which play an important role in the development of prostate cancer. The test could be used to identify new drugs to treat prostate cancer, as described in the review journal. ASSAY and Medical Technology Development.

Approximately 75% of patients with chronic prostate cancer describe variants of isrogen receptors that do not have a ligand-binding region. These types of diseases avoid all forms of treatment of the isrogen receptor currently involved. The amino terminal region (NTD) of the androgen receptor is shown to be important to the receptor function. Iain McEwan, from the University of Aberdeen, and co-authors developed a major cell-based product. assess to identify and identify inhibitors of androgen-NTD receptors.

“We are demonstrating the relevance of the test for large display platforms and confirming the first two editions coming out of the smaller, more targeted, library screen in prostate cancer cells,” the researchers said.

“McEwan and colleagues are working to address the obvious, unpaid medical needs in prostate cancer. The impact of the translation of new drugs and remedy the remodeling and remodeling of this type of prostate cancer will be enormous, highlighting the importance of the new growth rate, ”he said. ASSAY and Medical Technology Development Editor-in-Chief Bruce Melancon, Ph.D., Director of Pharmacology at the Warren Center for the Discovery of Neuroscience at Vanderbilt University.


A new approach to prostate cancer imaging


Learn more:
Amy E. Monaghan et al, Androgen Receptor Splice Variants,,,,,,,,,,,,,,,,,,,, ASSAY and Medical Technology Development (2022). DOI: 10.1089 / adt.2021.128

hint: Research team develops a new trial of prostate cancer drugs (2022, April 6) retrieved 6 April 2022 from https://medicalxpress.com/news/2022-04-team-screening-assay- drugs-prostate.html

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Research team develops new screening assay for drugs targeting prostate cancer Source link Research team develops new screening assay for drugs targeting prostate cancer

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