Research shows investigational drug fosters nerve repair after injury

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Scientists from the University of Birmingham have shown that a candidate’s brain tumor currently being developed as a cancer treatment could improve the recovery of damaged nerves after spinal cord injury.

The researchpublished today in Clinical Medicine and TranslationCell and animal species were used to indicate that when used orally with a drug, known as Download: AZD1390can block responses to internal DNA damage nerve cells and improve renewal of damaged nerves, so focus as well car work behind spinal cord injury.

The announcement comes weeks after the same research team showed a different research drugs (AZD1236) can reduce damage after spinal cord injury, by blocking the inflammatory response. All of these studies are supported by the AstraZeneca Innovation Program, which shares compounds, tools, techniques and expertise with the scientific community to improve drug discovery and development.

The AZD1390 is also under AstraZeneca research to block ATM-dependent signals and repair two-dimensional DNA sequences (DSBs), a level of self-awareness. Cells to radiation therapy. The DNA damage response mechanism is activated by DNA damage, including DSBs in the organism, which occur in many cancers and after spinal cord injury.

Professor Zubair Ahmed from the University’s Center for Disease Control and Aging and Dr. Richard Tuxworth of the Center for Cancer Research and Biology predict that continued activation of this system could prevent recovery from spinal cord injury, and block it. will promote nerve repair and recovery. work after injury.

Their first study found that AZD1390 stimulates nerve cell proliferation in normal, and inhibits the ATM protein kinase pathway – a key biochemical mechanism that regulates responses to DNA damage.

The researchers used an animal model to investigate the impact of AZD1390 after spinal cord injury. Here they show that oral therapy with AZD1390 results in significant inhibition of the ATM protein kinase pathway, nerve regeneration beyond the site of injury, and the ability of these nerves to carry electrical signals across the site of injury.

Professor Ahmed commented: “This is an exciting time in the study of spinal cord injury with a number of different research drugs identified as ways to treat spinal cord injury. We are very excited about and AZD1390 which can be taken orally and reach the injured area in large numbers.To improve nerve regeneration and restore lost function.

“Our findings show a remarkable resurgence of mental and motor functions, as well as AZD1390 performed in non-healthy animals and non-healthy animals within 4 weeks of injury.”

DR. than creating a new treatment from scratch. ”

The University of Birmingham Enterprise has filed a patent application that covers the prevention of ATM / Chk2 DNA damage by compounds such as AZD1390, which may represent therapeutic strategies for enhancing nerve repair.

Research brings hope for the treatment of spinal cord injuries

Learn more:
Ahmed Z, Tuxworth RI. The intracellular ATM inhibitor, AZD1390, promotes axon recovery and functional recovery in the spinal cord. Clinical Medicine and Translation (2022). DOI: 10.1002 / ctm2.962

hintResearch shows research studies have improved nerve repair after injury (2022, July 12) retrieved 12 July 2022 from .html

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