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Replacing microglia in mice using circulation-derived myeloid cells to treat neurodegenerative disease

Science Interpretation (2022). DOI: 10.1126 / scitranslmed.abl9945 “width =” 800 “height =” 530 “/>

CDMCs have similarities and functionalities but differ from microglia. (A) Representative images of Iba-1 + in the cortex of untreated mice (-), mice after BMT + P (12 weeks after transplantation), and mice after BMT + P (24 weeks after transplant). The sections below are large images of boxed areas in large sections. Scale bars, 50 (m (top) and 25 (m (bottom). (B) Statistical analysis, biology of Iba-1 + in the samples shown. Left: Total length of process. Middle: Number of branch areas. Right: Cell number (horizontal bars represent median values, n = 3 per group, three brains per animal; *** P Science Translational Medicine (2022). DOI: 10.1126 / scitranslmed.abl9945

An international team of researchers has developed a method to replace almost all microglia in the mouse brain by using myeloid cells obtained from various sources as a means to treat neurodegenerative diseases by using and technology that does not require the control of the molecules of either the host or the transmitter. In their paper published in the journal Science InterpretationThe team unveiled their new technology and the improvements they have seen in rats after treatment with the new method.

One of the ways doctors try to treat others neurodegenerative diseases by therapies. But such a system often prevents it by making it difficult for cells to divide as soon as they are transplanted into a patient. In this new attempt, the researchers found a way to replace a defective cell type, known as microgliawith new ones.

Microglia exist in the brain – their job is to remove dead cells and identify and clear harmful proteins. Previous studies have shown that they play a role in the formation of memory and have linked some types of neurogenerative diseases to microglia deficiency. In this new attempt, the researchers sought to replace malignant microglia into another mouse brain with microglia from other harmless mice. Their method involves giving the rats a drug that kills microglia in their brains and then replacing them with the underlying condition. myeloid cells– such cells can attach themselves to the brain where they produce microglia.

Experiments with a new system with mice with neurodegenerative diseases associated with low microglia (where they have low normal prosaposin levels) have shown the potential to be effective. Those mice that received the transplant had a low brain tumor, had a long life span and showed excellent motor skills.

After that, the research team will test their strategies with the monkeys. They will also look at ways to reduce toxins, and plan to study the new microglia produced in the brain to see if they can identify the differences between them and the disabled that replaced them.


Identifies the ‘ci-ni’ signal that is involved in synaptic pruning and maturation of new neurons in adult brains.


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Yohei Shibuya, et al Science Interpretation (2022). DOI: 10.1126 / scitranslmed.abl9945

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