Health

Real-world data links rosuvastatin with signs of kidney damage

Journal of the American Psychological Association (2022). DOI: 10.1681/ASN.2022020135″ width=”800″ height=”450″/>

Graphic design. Credit: Journal of the American Society of Nephrology (2022). DOI: 10.1681/ASN.2022020135

Statins can effectively lower cholesterol, and many people take rosuvastatin, one member of this class of drugs. New research based on patient health data is also published in Journal of the American Society of Nephrology suggests that rosuvastatin, especially at higher doses, may be harmful to the kidneys.

Reports linked rosuvastatin with signs of kidney damage – hematuria (blood in the urine) and proteinuria (protein in the urine) – when it was approved by the US Food and Drug Administration, but there was little post-marketing surveillance. to determine the real. – world adventure. To investigate, Jung-Im Shin, MD, Ph.D. (Johns Hopkins Bloomberg School of Public Health) and colleagues analyzed electronic health record data for 152,101 new users of rosuvastatin and 795,799 new users of a statin called atorvastatin from 2011-2019.

In a median follow-up of 3.1 years, the team found hematuria in 2.9% of patients and proteinuria in 1.0% of patients. Compared to atorvastatin, rosuvastatin was associated with an 8% higher risk of hematuria, a 17% higher risk of proteinuria, and a 15% higher risk of hypertension. kidney failure replacement therapy such as dialysis or transplantation is needed. The risk of hematuria and proteinuria is higher with higher doses of rosuvastatin. Also, in patients with kidney disease, 44% were prescribed a higher dose of rosuvastatin than the US Food and Drug Administration recommends for people with severe kidney function.

“We observed a higher risk of hematuria, proteinuria, and renal failure with the use of rosuvastatin and similar cardiovascular benefits between the rosuvastatin and atorvastatin groups,” said Dr. Shin. “Because rosuvastatin can cause proteinuria and hematuria, especially with high doses, high doses of rosuvastatin may not be worth the risk—even if it’s small—especially for patients with kidney disease.”


LDL reduction in hypertriglyceridemia is different for each statin


Additional information:
Jung-Im Shin et al, Association of Rosuvastatin Use with Risk of Hematuria and Proteinuria, Journal of the American Society of Nephrology (2022). DOI: 10.1681/ASN.2022020135

hintReal data links rosuvastatin to symptoms of kidney damage (2022, July 19) Retrieved July 19, 2022 from https://medicalxpress.com/news/2022-07-real-world-links-rosuvastatin-kidney.html

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Real-world data links rosuvastatin with signs of kidney damage Source link Real-world data links rosuvastatin with signs of kidney damage

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