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Potent intracellular antiviral activity of human IgG3 depends on the hinge region

Intracellular antiviral activity of human IgG3 hinge on hinge. Credit: Called by Stian Foss using BioRender

Humans have developed four different types of IgG immunity that regulate protection against infection. Understanding the genetic and cellular properties of how these contribute to the rapid elimination of viral infections may lead to the development of “super-antibodies” that can be effective treatment and protection against viruses. developing diseases of the forearm but also for symptoms beyond the coronary arteries.

While vaccine is well known for its protection against bacterial infections extracellular space, a study by Leo James Laboratory at the MRC’s Molecular Biology Laboratory changed this theory by highlighting the important role of the cytosolic antibody receptor, TRIM21, in eliminating the virus before it has time to copy and spreading. Through numerous studies in collaboration with the Laboratory of Adaptive Immunity, led by Professor Jan Terje Andersen, at the University of Oslo and the University Hospital of Oslo, new knowledge has been discovered about the relationship between immune system and function.

In the current project, it is published in Immunologythey expand this by indicating that the four man IgG subclasses carry different cytosolic Fc TRIM21 receptors that follow the intended damage. virus and input the original signal. Importantly, they revealed that IgG3 is higher compared to the other three groups, and this strong activity depends on the long and flexible area. In addition, they show that this is also the case for the protection of viruses through a suitable cell.

“We have a small fraction of IgG3 in our body at all times, which is related to specific values ​​and the fact that it has extracellular activity. So, it is surprising that it is not lax. In this study, we presented a comprehensive analysis of the structure of its specific structure in the context of infection. in the internal endosomes and in the cytosolic space, ”he said. first author of the study Stian Foss, Researcher in the Department of Pharmacology, University of Oslo.

“Human IgG3 has been linked to improved control or protection against pathogens, including viruses. how this knowledge can be used in IgG gene engineering with mutations and even better functionality than natural IgG3, ”said Jan Terje Andersen, lead author of the study.


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According to Stian Foss et al, TRIM21 daƘ da da da da da da da da da da da da da da yana ciki yana yana yana yana yana yana yana Immunology (2022). DOI: 10.1126 / sciimmunol.abj1640. www.science.org/doi/10.1126/sciimmunol.abj1640

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University of Oslo

hintHuman antiviral activity of human intracellular IgG3 depends on the hinge region (2022, May 2) restored May 2, 2022 from https://medicalxpress.com/news/2022-05-potent-intracellular-antiviral-human- igg3.html

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