Health

Porous cells lead to poorer livers

Too much fat weakens the intestinal barrier function, causing migration and accumulation of lipoteichoic acid in the liver. Accumulated lipoteichoic acid causes a decrease in the gasdermin D protein, forming cell pores where SASP IL-1β and IL-33 substances are released from liver cells. IL-33 activates regulatory T cells that inhibit the immune response, enhancing cancer progression. Credit: Osaka Metropolitan University

Need some reason to think twice before ordering more fried help? It can increase the risk of developing liver cancer. Non-alcoholic steatohepatitis (NASH) —a type of fatty liver disease that can also lead to cancer — is on the rise, and treatment is difficult. A research team led by the University of Osaka Metropolitan has taken a step that could lead to the suppression and treatment of NASH-related liver cancer with their study using obese rats revealing the importance of protein hidden in holes a membrane cell formed in the cells around the cancer cells inside. tumor microenvironment for cancer development. Their search results are published in Immunology.

While cancer cells are obviously harmful, neighboring cells including cancer-related fibroblasts in the so-called “cancer state” may play a role in cancer growth. “In the liver associated with obesity additional microenvironmentfibroblasts called hepatic stellate cells have become more sensitive, “said lead researcher Professor Naoko Ohtani. ‘i of proteins that promote cancer by inhibiting antibiotics. The mechanism by which proteins are extracted such as SASP elements and enhanced growth factor remains unknown.

Professor Ohtani’s team tried to figure out this process by feeding a a lot of food to rats infected with cancer and the study of liver cancer caused by obesity. They first conducted a detailed genetic analysis to determine what SASP factors produced by stelate cells of the liver and then investigated how they were released.

SASP IL-1β and IL-33 have been identified as two of the major risk factors for liver cancer. Their release takes place in two major stages. “First, a high-fat diet weakens the intestinal barrier function, which leads to migration and accumulation of lipoteichoic acid in the liver,” Professor Ohtani adds. “Second, the accumulation of lipoteichoic acid results in a decrease in the protein gasdermin D. This, in turn, causes pores of the cell membrane where IL-1β and IL-33 are excreted or excreted from the stellate cells. liver.”

These pores play an important role, because once IL-33 is released, it activates T receptor cells that work to suppress the cells. immune response you cancer cells and can lead to the development of cancer.

Understanding this process is an important development in the human war itself. “Our study reveals an interesting way in which SASP-enhancing substances are released through cell membrane pores formed by the movement of cells,” says Professor Ohtani. “Preventing this virus can facilitate prevention and treatment strategies for NASH affiliates. liver disease sick. ”


A new function of non-coding RNA in the body itself


Learn more:
Ryota Yamagishi et al, Gasdermin D-release of IL-33 from hepatic stellate stem cells promotes hepatic cell carcinoma, Immunology (2022). DOI: 10.1126 / sciimmunol.abl7209. www.science.org/doi/10.1126/sciimmunol.abl7209

Provided by Osaka Metropolitan University

hintWeak cells cause weakened liver (2022, June 24) Retrieved 24 June 2022 from https://medicalxpress.com/news/2022-06-porous-cells-poorer-livers.html

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