New study reveals characteristics of stable Vitiligo skin disease

Additional images of multiphoton microscopy (MPM) of drug-resistant patients showed that physically altered keratinocytes develop in those who do not respond but are normalized in the responders. Credit: UCI School of Medicine

A new study, led by researchers from the University of California, Irvine, reveals unique communication pathways to the cell that can promote inflammation and prevent regmentation in patients with vitiligo.

The study, entitled, “Multimodal Analyzes of Vitiligo Skin Detects Fungal Characteristics of Infectious Diseases,” was published today. JCI prices.

“In this study, we combined image development with transcriptomics and bioinformatics to identify cell-to-cell networks between keratinocytes, antibiotics and melanocytes that drive inflammation and prevent regmentation damage by vitiligo“says Anand K. Ganesan, MD, Ph.D., professor of dermatology and vice president of dermatology at UCI School of Medicine.” This study will allow us to understand why whites continue to develop continue to be a victim of vitiligo, which leads to illness. could lead to new therapies to treat the disease. ”

Vitiligo is a highly contagious disease that manifests itself in the breakdown of melanocytes, which are the adult producers of melanin in the skin, by an autoreactive virus called CD8.+ T cells that cause irregular white patches. This disease has been shown to cause significant anxiety among patients. Melanocyte degradation in active vitiligo is mediated by CD8+ T cells, but so far, why the white patches in the stable are not well understood.

“Still, interactions between viruses, melanocytes, and keratinocytes in the site human skin it has been difficult to study due to the lack of advanced equipment, “said Jessica Shiu, MD, Ph.D., assistant professor of dermatology and one of the leading authors of the study.” By combining multiphoton microscopy without non-degradation (MPM) Imaging and single-cell RNA (scRNA-seq) sequence, we identified different keratinocytes of keratinocytes in weakened stable skin patients with changes in cellular connective tissue in stable vitiligo skin that causes persistent disease. In patients who have responded to freezing therapy, these changes are reversible, highlighting their role in the development of the disease. “

MPM is a unique tool that has a wide range of applications in the human skin. MPM is an advanced magnetic field technology that can produce images with low micron resolution and molecular markers that can be used to characterize keratinocyte metabolism in human skin. They are keratinocytes Epidermal cells which produces keratin.

Most studies on vitiligo have focused on functional disorders, while stable vitiligo remains a mystery. Investigations are currently underway to determine when life changes were made keratinocytes first explain and how they may affect the reigmentation process in patients undergoing treatment.

The results of this study increase the likelihood of increased keratinocyte metabolism in vitiligo treatment. Further studies are needed to improve our understanding of how keratinocyte states affect muscle tissue and contribute to disease progression.

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Learn more:
Jessica Shiu et al, Multimodal study of vitiligo skin identifies stable tissue reactions, JCI prices (2022). DOI: 10.1172 / jci.insight.154585

hintNew study reveals characteristics of Vitiligo skin disease (2022, June 6) Retrieved 6 June 2022 from

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New study reveals characteristics of stable Vitiligo skin disease Source link New study reveals characteristics of stable Vitiligo skin disease

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