Hematopoietic stem cells (HSCs) have the ability to regenerate and differentiate into any type of blood cell and adult, making them promising to treat a wide range of diseases. However, the mechanisms involved in transplantation — when cells begin to grow and produce healthy blood cells after transplantation — are not well understood. A recent study led by researchers at the Massachusetts General Hospital (MGH) and the Boston University School of Medicine revealed the unique signaling genes that the HSC described as potentially resistant to this process. The results of the study, published in Environmental communicationit can allow scientists to expand these cells outside the body or to convert certain types of cells into cells that can re-invade the bloodstream.
In adults, HSC is found in the bones and tendons blood, but before they are born, they can be found in large numbers in the liver, where they multiply, or proliferate, into additional HSCs in large numbers. In addition, research in animals has shown that HSCs in the fetal liver are more potent than HSCs in the bones.
To understand what allows HSCs the liver to receive these enhancement and enhancement enhancements, researchers have examined the molecular expression patterns that characterize these powerful bases. Cells. They combined this experiment with different experimental methods to characterize the expression of protein and the function of those single cells.
“This in-depth study shows that these cells express a protein capsule on top of them called CD201 that is closely related to this potential and can be used to differentiate active cells from other cell types, ”said lead author Alejandro B. Balazs, Ph.D., senior researcher at the MGH, MIT and Harvard Lamb Center. “This will help us improve the system bones and transplantation by enabling us to purify these organisms. “
Improved understanding of the genes involved will also enable scientists to disseminate HSCs with the potential to upgrade in the laboratory and process them to fight diseases related to blood vessels such as them. sickle cell anemiaHIV and other strains cancer. “Overall, this work has resulted in a more detailed analysis of the blood’s powerful cells and will lead to a better understanding of why these cells have such a remarkable ability to regenerate. Such an understanding will allow us to create more safe and effective therapies for patients. are suffering from anemia, ”said lead author Kim Vanuytsel, Ph.D., assistant professor of medicine at Boston University School of Medicine.
Senior author George J. Murphy, Ph.D., professor of medicine at Boston University School of Medicine and founder of the BU and BMC Center for Rehabilitation Medicine (CReM), adds that the group is clearly divided resources. which is made available in a flexible format in https://engraftable-hsc.cells.ucsc.edu, will allow for a new understanding of biology about the potential for enhancing and enhancing future reading. “This important project would not have been possible without the strong, collaborative university that took place between Boston regional institutions. This project is also a shining example of ‘open biology’ in the workplace where data can be used. given the gift and mutual understanding. for future discovery, “he said.
Co-authors include Carlos Villacorta-Martin, Jonathan Lindstrom-Vautrin, Zhe Wang, Wilfredo F. Garcia-Beltran, Vladimir Vrbanac, Dylan Parsons, Evan C. Lam, Taylor M. Matte, Todd W. Dowrey, Sara S. Kumar, Mengze Li, Feiya Wang, Anthony K. Yeung, Gustavo Mostoslavsky, Ruben Dries, Joshua D. Campbell, and Anna C. Belkina.
Kim Vanuytsel et al, Multi-modal profileing of human liver liver hematopoietic stem cells express signature genetic engraftment, Environmental communication (2022). DOI: 10.1038 / s41467-022-28616-x
Massachusetts General Hospital
hint: New research could help improve bone marrow transplantation and cell transplantation for patients with blood-borne diseases (2022, March 1) Retrieved 1 March 2022 from https://medicalxpress.com/news/ 2022-03-bone-marrow-stem- cell-transplants.html
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