New paper reviews gut microbiome health role in fighting depression during COVID-19 pandemic

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Researchers at Case Western Reserve University, University Hospital Cleveland Medical Center (UH), BIOHM Health LLC, and Louis Stokes Cleveland VA Medical Center have published their papers. Nutrition frontier, COVID-19 Proposes hypotheses and theories about a microbiota-driven approach to combat depression during a pandemic.

In their treatise, Mahmoud A. Ghannoum, Ph.D., FAAM, FIDSA, and colleagues are surprised that the serious stressors caused by COVID-19 and exacerbated are related to mental health disorders, especially depression. I write that it is related to the surge in power.

Within the first month of the COVID-19 pandemic, researchers reported anxiolytic prescriptions increased by 34.1%, antidepressant prescriptions increased by 18.6%, and generally increased by 14.8%. I am. Anti-insomnia medications, including anti-insomnia medications prescribed in the United States.

“In such a short period of time, this sharp rise suggests the magnitude of the immediate and widespread effect of COVID-19 on mental health,” said the director of the UH Center for Medical Mycology, Dermatology and Dr. Ghannoum, a professor of pathology, said. Case Western Reserve University School of Medicine.

In their treatise published on August 24, Dr. Ghannoum and his colleagues Microbiota The cerebrointestinal axis to advance a potential complementary approach to coping with depression and depressive disorders that increased during the COVID-19 pandemic.

“The impact of the human gut microbiota on emotional health is a emerging area,” said Dr. Ghannoum. “More research needs to be done, but the current evidence is very promising, suggesting that at least some of the answers to a deeper understanding of depression may be in the microbiome. I am. “

The microflora is defined as the collective genome of microorganisms (composed of bacteria, fungi, protozoa, and viruses) that live inside and above the human body, but primarily in the human intestine. Scientists are learning that these microbes play an important role in health and illness.

Studies also suggest that the microbiome affects our brain and emotions. The gut microbiota and the brain communicate with each other through nerve, inflammation, and hormonal signaling pathways. As a result of the two-way interaction between the gut flora and the brain, each can send a message that affects the other.

Dr. Ghannoum and colleagues carefully annotate the microbiome, and that a microbiota-based holistic approach, including potential changes due to diet, probiotics, and lifestyle changes, may address depression. Is proposing.

“Despite the sacrifices that depression makes to both individuals and society, it is difficult to understand and effectively treat depressive disorders,” said Dr. Ghannoum. “Current research into the diagnosis and treatment of depression and mood disorders is ongoing, but more time is needed to develop the complexity associated with how to treat them.”

He highlights the potential correlation between COVID infection and microbiota disorders in some studies, but with limitations that need to be further investigated with a larger sample size to estimate the general population. Said there is.

However, researchers have found more evidence to support the gut-brain relationship and the relationship between depression and the gut microbiota. They see this connection as a potential new and more effective target for depression management.

“It is clear that the composition of the gut microbiota in people with depressive disorders has been disrupted and there is a lack of beneficial levels of beneficial microorganisms,” said Dr. Ghannoum. “We see that promoting the growth of such beneficial microorganisms and rebalancing an individual’s gut flora is promising to help individuals relieve depression through the intestinal brain axis. I believe it might be a step. “

Researchers have proposed a multifaceted approach to managing depression, including rebalancing and maintaining the gut microbiota through diet, probiotics, and certain lifestyle changes. increase. Specifically, we are looking for the following:

  • A healthy diet of fruits and vegetables. These nutrients appear to be associated with reduced depression rates, probably due to their anti-inflammatory, neuroprotective, and prebiotic properties, “says Dr. Ghannoum.
  • Probiotics that play an important role in rebalancing and treating microbiomes depression..
  • Lifestyles such as exercise, sleep, and stress reduction.

They write: “Probiotic consumption may not only restore intestinal balance, but also reduce the likelihood of intestinal colonization by opportunistic pathogens. Gut microbiota In patients with COVID-19 infection. ”

Linking mental health with the gut microbiota

For more information:
Mahmoud A. Ghannoum et al, COVID-19 Microbiota-driven approach to combat depression during a pandemic, Nutrition frontier (2021). DOI: 10.3389 / fnut.2021.672390

Quote: A new treatise reviews the role of gut microbiota in the fight against depression during the COVID-19 pandemic (August 25, 2021). .html

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New paper reviews gut microbiome health role in fighting depression during COVID-19 pandemic Source link New paper reviews gut microbiome health role in fighting depression during COVID-19 pandemic

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