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New imaging technology less accurate than MRI at detecting prostate cancer, trial shows

Prostate cancer cells. Credit: NIH Photo Gallery

A team of researchers in Australia and New Zealand found that MRI scans could detect prostate cancer more accurately than new prostate cancer -PSMA PET / CT technology.

The results of the study are being presented today at the annual meeting of the European Association of Professional Engineers (EAU22), in Amsterdam.

Prostate-specific membrane antigen (PSMA) PET / CT scans, approved by the US FDA in 2020, use radio dye to ‘light’ PSMA areas, found at the top prostate cancer Cells. They are currently used to control prostate cancer, because they can measure the progression or recurrence of the disease accurately. So, in this experiment the researchers set out to find out if they could be used to diagnose prostate cancer.

The PEDAL trial employed 240 patients in five hospital groups who were at risk of developing prostate cancer. Each patient was given both an MRI scan and a PSMA PET / CT scan. If the picture shows the presence of prostate cancer, the urologist does a biopsy.

MRI scans took an inconsistency in 141 patients, while PSMA PET / CT scans took an inconsistency in 198 patients. A total of 181 patients (75%) were tested for prostate cancer, and were later diagnosed. 82 of those patients had prostate cancer at the hospital.

Since each patient has two types of prostate cancer, researchers can determine which type is most likely to detect those with prostate cancer. The researchers found that MRI scans were more important in diagnosing any type of prostate cancer than PSMA PET scans (0.75% of MRI vs 0.62% of PSMA PET).

Assistant Professor Lih-Ming Wong, Consultant Uro-oncologist at St Vincent Hospital in Melbourne, Australia, led the research team. He said: “Our study found that MRI scans are better than PSMA-PET to detect any form of prostate cancer. When we looked only at clinical prostate cancer, there was no difference in accuracy. According to this study is one of the first to diagnose cancer.resected using PSMA-PET to detect cancer in the prostate, we are still learning and adjusting how to improve using PSMA-PET in this setup.

Although the detection thresholds will be adjusted as the disease progresses, Professor Wong believes the test has important lessons for physicians.

He said: “This study confirms that the ‘gold standard’ of pre-biopsy-MRI detection is indeed a major measure. Even with the adjustment, we suspect PSMA PET / CT will not replace MRI in as a major factor.The method of detecting prostate cancer, but may be used in the future as a combination for MRI, or for people who are not suitable for MRI, or as a “diagnostic and staging” single combination to select the appropriate one. patients. “

He continued: “This is why these kinds of powerful studies are so important so we can better understand the role that these technologies can play at every stage of cancer progression, and eating in the treatment of prostate cancer. “

Professor Peter Albers, President of the European Union’s Office of Urology, comments: “New research tools need to be tested as carefully as new drugs, so we welcome the results of this great Phase III experiment, which suggests that MRI is outstanding in detecting any prostate cancer.

“It also shows that PSMA PET / CT is no less than MRI in the diagnosis of clinical malignancies (ISUP 2 and higher); and since the primary goal is to detect only acute and chronic cancer. avoiding unnecessary biopsy, This is not the end of the article. Further research will be needed to investigate the relationship between PSMA PET / CT between standardized exercise (SUV) and self-harm, but first steps below to find the best way to diagnose the disease for a critical hospital. prostate cancer is taken. ”


PSMA PET confirms EAU classification system to assess risk of prostate cancer recurrence


hint: New imaging technology no better than MRI in diagnosing prostate cancer, tests show (2022, July 4) restored 4 July 2022 from https://medicalxpress.com/news/2022-07-imaging- technology-accurate-mri-prostate. html

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