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New hope to help advanced Parkinson’s patients walk, sleep again

A soft rubber mat designed to fit the dura mater. Credit: Neurorestore / Jimmy Ravier

People with Parkinson’s often struggle to walk more than a few steps or sleep through the night, but new research offers hope of relief from these two debilitating symptoms.

Millions of people around the world suffer from the disease, a disease that impairs exercise and in its later stages often confines patients to a bed or wheelchair.

This is due to a condition called orthostatic hypotension, which occurs when a person stands up and lowers their blood pressure, causing dizziness and even fainting after two steps.

For Parkinson’s sufferers, this is because a brain regulator – which usually ensures enough blood flow to the brain when we wake up – is damaged.

But a new French study published in New England Journal of Medicine Last week he discovered that implanting a spinal cord can help Parkinson’s patients who have developed to regain control of their feet.

The quality of life has improved

Earlier this year nurses Jocelyne Bloch and Gregoire Courtine announced that the implant had caused three paralyzed to walk again.

Both also participated in a new study, which tested a similar plant on a 48-year-old woman.

While the woman did not have Parkinson’s disease, she had similar symptoms — including orthostatic hypertension — she was initially diagnosed with Parkinson’s disease.

For paralyzed individuals, implanting the spinal cord mimics how the brain sends electrical impulses to the muscles, reconnecting the cut path.

As for orthostatic hypertension, it stimulates a regulator in the brain that feels the need to send more blood when people are standing up.

Before the baby is born, the woman will faint after taking some steps.

Three months after the surgery, she was able to walk more than 250 meters (820 feet) with the help of a walking frame, the study said.

“She has not recovered, she will not run marathon, but this surgery has clearly improved her life,” Bloch told AFP.

However it is a single case and further investigation is needed, especially one involving Parkinson’s patients.

It has not yet been proven that orthostatic hypotension seen in Parkinson’s patients can be corrected only by direct intervention. plant attack.

Anti-insomnia pump

Insomnia is a common epidemic for 10 million people with Parkinson’s disease worldwide, with more than three-quarters having symptoms of insomnia, according to the Parkinson Foundation.

Uncontrolled seizures can affect the sleep patterns that wake patients up, while another factor is the lack of dopamine, which is common for Parkinson’s sufferers.

Apomorphine is usually used to replace dopamine, reducing the symptoms of tremors and stubbornness.

But when taken orally, the drug can cause dopamine to increase and then drop, causing muscle spasms.

A similar device insulin pump who gives apomorphine in the dark at night can solve the problem, according to a study published in the journal Lancet Neurology on Thursday.

Author Emmanuel Flamand-Roze led a previous study that suggested that such a pump would help with Parkinson’s disease, but a new study looked at how it helps with sleep.

A randomized study found that those who used the pumps had a “better sleep” compared to those who received a placebo.

Flamand-Roze told AFP that “the problems associated with installing a small pump” were very low at night, compared to carrying such a device throughout the day.

However because the study is yes small sample size– less than 50 people — and focused on people at Parkinson’s developmental stage, further research is needed.


Electrical implantation reactivates the spinal cord nerves of patients with neurodegenerative diseases


Learn more:
Jordan W. Squair et al, Planted for Orthostatic Hypotension in Multiple Processes, New England Journal of Medicine (2022). DOI: 10.1056 / NEJMoa2112809

© 2022 AFP

hintNew Hope to Help Advanced Parkinson’s Patients Walk, Sleep (2022, April 14) Retrieved 14 April 2022 from https://medicalxpress.com/news/2022-04-advanced-parkinson-patients.html

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