Neurological symptoms persist in majority of long-haulers

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Researchers at the University of California San Diego School of Medicine are conducting a long-term study to track the symptoms of viral infections in COVID-19 “long-term carriers.”

Results of the first round, published June 15, 2022 in Journal of Clinical and Interpreting Neurologydescribed a number of different short- and long-term symptoms and found that, while most patients showed improvement, many still had some. neurological symptoms after six months. Groups of people also exhibited collaborations and important topics, which were not previously described.

Following moderate to moderate SARS-CoV-2 infection, 56 individuals with neurological symptoms were taken to the study between October 2020 and October 2021. They completed neurological testing, cognitive assessment, self-reported interviews and selective memory test. The original measure was taken a few months after them primary infection and repeated after three and six months.

During their first visit, 89 percent of the participants suffered from fatigue and 80 percent reported headaches. Other symptoms of chronic arterial hypertension include memory loss, insomnia and dizziness. Eighty percent of the participants said that these symptoms affected their quality of life.

When participants returned for their six-month follow-up, only one-third reported full resolution of symptoms. The other two-thirds of the participants reported progression of symptoms, although the majority decreased with severity. The most common symptoms within six months are memory loss and decreased concentration.

The authors noted that none of the individuals had any signs of progression at six months with a previous history of vascular condition prior to SARS-CoV-2 infection.

“It’s interesting that a lot of people are showing some progress over the next six months, but that’s not the case for everyone,” said lead author Jennifer S. Graves, MD, Ph.D., Associate Professor at UC San Diego School of Medicine and neurologist at UC San Diego Health. “Some of these participants are highly skilled participants who we would expect to receive above average grades on cognitive value, but months after receiving COVID-19, they are still valued.”

The researchers were also surprised to find a new style of phenotype in the group. Seven percent of participants exhibited previously unrecognized symptoms that included poor comprehension, nervousness and difficulty adjusting. The authors labeled the Post-Acute Sequelae phenotype of COVID-19 infection with Tremor, Ataxia and Cognitive Behavior (PASC-TAC).

“These are people who did not have vascular problems before COVID-19, and now have a normal body balance and the ability to adjust their thinking,” Graves said. “We didn’t expect to get this, so we’d love to hear if other doctors also saw this.”

Researchers are still working to determine how much SARS-CoV-2 virus directly infects the brain, but Graves said it is possible that these slowing down symptoms are caused by an infection that triggers an inflammatory response in the brain. .

The team plans to continually monitor participants’ symptoms each year for up to 10 years. Further efforts will evaluate how long-term differences in COVID-19 and vaccines affect neurological symptoms.

“To get people’s understanding and quality of life still impacting long after infection is something our society really needs to study,” Graves said. “We still need to know how common this is, what it is biological methods causes this, and what further health care these people will need. This is a very important step in getting there. ”

The long-term cause of COVID is still unknown

Learn more:
Jacqueline E. Shanley et al, Long-term evaluation of neurologic-post acute sequelae SARS-CoV-2 symptoms, Journal of Clinical and Interpreting Neurology (2022). DOI: 10.1002 / acn3.51578

hintCOVID-19 on the brain: Nerve symptoms persist in most long-distance travel (2022, June 15) Retrieved 15 June 2022 from neurological-symptoms- nace.html

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Neurological symptoms persist in majority of long-haulers Source link Neurological symptoms persist in majority of long-haulers

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