Maternal COVID-19 infection increases risks of preterm birth, low birth weight and stillbirth

Creative representation of SARS-CoV-2 particles (not proportional to actual size). Credits: National Institute of Infectious Diseases, NIH

People infected with COVID-19 during pregnancy are more likely to have poor birth outcomes, including preterm birth, low birth weight infants, low birth weight infants, and stillbirths. Poor results of preterm birth and stillbirth were observed primarily in people infected with SARS-CoV-2 during the first or second trimester, but the rate of increase in low birth weight infants of gestational age was predominantly third. Caused by a trimester infection.

A study led by the Institute of Systems Biology examined electronic health records of more than 18,000 people who underwent SARS-CoV-2 testing during pregnancy. The researchers compared the results of unvaccinated people (882 in total) who tested positive during pregnancy to those who tested negative.

“We found that SARS-CoV-2 infection mainly showed an increase in preterm birth and stillbirth. Second semester “Infectious diseases,” said Dr. Samantha Piecos, lead author of the study. “The only largest predictor of gestational age at birth is gestational age at infection, and gestational age at infection. Is related to the age at birth. “

The subjects of the study were mild or moderate SARS-CoV-2 infections.The severity of maternal COVID-19 infection was not correlated Gestation period At the time of delivery. Moreover, even if maternal COVID-19 did not cause serious respiratory problems during infection, the outcome of childbirth was poor.

The findings were published in the journal today Lancet Digital Health And it is one of the first to explain the trimester of SARS-CoV-2 infection in the outcome of childbirth.

People in the SARS-CoV-2 positive cohort have been found to be associated with Hispanics, non-Asian or non-white races, Medicaid insurance, younger age, higher BMI, lower education level, and negative birth outcomes. It was likely to have other factors that have been. To explain this and make a true apple-to-apple comparison, researchers used statistical matching techniques to control confounding variables.

“Pregnant people are at increased risk of adverse consequences after SARS-CoV-2 infection, even if their mother’s COVID-19 is less severe, and may benefit from enhanced post-infection monitoring. There is, “said the ISB paper and assistant professor. “COVID-19 increases the risk of both maternal and fetal health, so this emphasizes the importance of protection. Pregnant female, “She added.

This study was conducted before the COVID-19 vaccine became widely available in the United States. There are opportunities for future research to see if vaccination helps prevent negative birth outcomes in breakthrough cases.

This research project was a collaboration between ISB and Providence.

The study states that the COVID-19 vaccine does not increase the risk of preterm birth.

For more information:
Impact of Maternal SARS-CoV-2 Infection Timing on Birth Outcomes: Retrospective Multicenter Cohort Study, Lancet Digital Health,… (21) 00250-8 / fulltext

Provided by Systems Biology Research Institute

Quote: Maternal COVID-19 infection increases the risk of preterm birth, low birth weight, and premature infants (January 13, 2022). birth.html

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