Health

Male contraceptive pill found 99% effective in mice

This photo taken on June 1, 2021 shows a mouse eating grain in the wheat holding Col Tink’s farm at the New South Wales Agricultural Center in Dubbo.

The team of scientists said on Wednesday they had developed a male contraceptive pill that contained 99 percent of the rat drug and did not cause any visible side effects, with the drug expected to enter the human test at the end of the day. this year.

The findings will be presented at the American Chemical Society’s summer conference, and highlight an important step in expanding contraceptive options — and for men —.

Since the first approval of contraceptives for women in the 1960s, researchers have been interested in a man like him, Md. Abdullah Al Noman, a graduate student at the University of Minnesota who will present the project, told The AFP.

“A lot of research shows that men are more interested in sharing the responsibility of contraception with their partners,” he said – but still, there are only two effective options available: condoms or vasectomies.

Performing Vasectomy exercises is expensive and not always successful.

The female ovum uses hormones to disrupt the menstrual cycle, and historically attempts to produce a male equivalent to the sex hormone testosterone.

The problem with this method, however, is that it causes side effects such as weight gain, stress and increased cholesterol levels known as low lipoprotein levels, which increases the risk of heart disease.

The ovaries also carry risks, including the risk of blood clotting — but since women are more likely to become pregnant if there is no contraceptive, the risk profile is different.

Non-hormone

To develop a non-hormonal drug, Noman, who works in Professor Gunda Georg’s laboratory, aims for a protein called “retinoic acid receptor (RAR) alpha.”

In the body, vitamin A converts them into various forms, including retinoic acid, which plays an important role in cell proliferation, sperm production, and fetal growth.

Retinoic acid needs to interact with RAR-alpha to perform these functions, and experimental studies have shown mice without the RAR-alpha gene.

For their work, Noman and Georg developed a field that blocked the RAR-alpha project. They found the best molecular model with the help of a computer model.

“If we know what a keyhole looks like, then we can make a better key – that’s where the calculation system comes in,” Noman said.

Their compounds, known as YCT529, are also designed to interact specifically with RAR-alpha, and not two other receptors associated with RAR-beta and RAR-gamma, to reduce the risk of side effects.

Five years market?

When given to mice for a period of four weeks, YCT529 reduced sperm count and was 99% effective in preventing pregnancy in the sex test.

The researchers observed weight, eating and general activity, with no adverse effects, although mice were not able to report side effects such as headaches or climate change.

Four to six weeks after being removed from the drug, the rats are able to reproduce again.

The team, funded by the National Institutes of Health and the Men’s Contraception Center, is working with a company called YourChoice Therapeutics to begin testing people in the third or fourth quarter of 2022, Georg said.

“I’m optimistic this will continue quickly,” she said, predicting a possible time for the market in five years or less.

She added: “There is no guarantee it will work … but I would be surprised if we do not see any effect on the human body.”

The persistent question about future contraceptives for men is whether women will be allowed to use them.

But research shows that more women will trust their partners, and a larger number of men suggest they will be ready for treatment.

“Male contraceptives will enhance the integration process, creating new options that allow men and women to contribute in any way they deem appropriate to the use of contraceptives,” said one non-profit organization. itself the Male Contraceptive Initiative, which provides support and advice.


Non-hormonal pills can expand men’s contraceptives sooner rather than later


© 2022 AFP

hintMale contraceptives were found in 99% of mice (2022, March 26) and recovered 26 March 2022 from https://medicalxpress.com/news/2022-03-male-contraceptive-pill-effective-mice .html

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