Survivors of young and old (AYA) hematological cancer increase the risk of secondary neoplasms, hospitalizations, and overall mortality, according to a study published online February 25 in Frontiers in Oncology.
Annalisa Trama, MD, Ph.D., from the Fondazione IRCCS Istituto Nazionale dei Tumori in Milan, Italy, and colleagues examined the long-term effects of AYA survivors and hematological cancers. Patients diagnosed with primary hematological cancer between 1997 and 2006 in the Italian population of AYA cancer survivors. Average number of events (SIRs), standardized clinical scores (SHRs), and average mortality rates (SMRs) were calculated for 5,042 AYA survivors of leukemia: 1,237 with leukemia and 3,805 with diagnosis of lymphoma.
The researchers found that survivors of AYA were at high risk for secondary infections, hospitalizations, and overall. mortal (SIR, 2.1; SHR, 1.5; and SMR, 1.4, respectively), with differences seen for leukemia and survivors of lymphoma. Infectious Diseases, respiratory diseases, and diseases of the blood vessels and organs that cause bleeding are the highest risk factors for hospitalization. Over time, the nature of the disease varies with the type of disease.
“Our study, evaluating a wide range of diseases, suggests that adolescents and young people with leukemia face a higher risk (at least 20 years from diagnosis) for different types of disease, suggests the need to follow up on a thorough evidence. plans to survive, designed to increase the likelihood of early detection and ultimately prevent the conditions that lead to routine treatment, ”the authors wrote.
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