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Long term exposure to air pollution linked to heightened autoimmune disease risk

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Long-term exposure to air pollution is associated with an increased risk of autoimmune diseases, particularly rheumatoid arthritis, joint pain and inflammatory bowel disease, has found published online research in open journals. RMD Open.

Environment air pollution from vehicle consumption and industrial emissions can lead to impaired immune function – as the body responds to specific pathogens. But sometimes this positive response is lost, leading to systemic inflammation. tissue damageand finally autoimmune disease.

Examples of autoimmune diseases include rheumatoid arthritis; system of lupus erythematosus; inflammatory diseases, such as ulcerative colitis; connective tissue diseases, such as osteoarthritis; and multiple sclerosis.

Both events and the prevalence of these conditions have increased dramatically over the past decade, reasons not fully explained. And whether air pollution is linked to an increased risk of autoimmune disease remains a matter of debate, the researchers said.

To test and shed light on the issues, the researchers excavated the Italian Dementia Risk Index (DeFRA) and retrieved medical data on 81,363 men and women submitted by more than 3,500 doctors between June 2016 and November 2020.

The majority are women (92%) with an average age of 65, and 17866 (22%) have at least one healthy condition together.

Each candidate is affiliated with the nearest air quality monitoring station operated by the Italian Center for Environmental Protection and Research by their home box number.

The researchers were interested in the impact of genetic factors (PM10 and PM2.5). Levels 30µg / m3 for PM10 and 20µg / m3 for PM2.5 are the gateways generally considered harmful to human health.

Some 9723 (12%) people contracted autoimmune disease between 2016 and 2020.

Data on air quality were obtained from 617 monitoring stations in 110 Italian provinces. The average long-term exposure between 2013 and 2019 was 16 µg / m3 for PM2.5 and 25 µg / m3 and PM10.

Exposure to PM2.5 is not associated with an increased risk of autoimmune disease detection. But PM10 is associated with an increase of 7% per 10µg / m3 increase in levels, after listing the factors that can influence.

Long-term exposure to PM10 above 30 µg / m3 and to PM2.5 above 20 µg / m3 They were associated with, respectively, 12% and 13% higher risk of autoimmune disease.

And long-term exposure to PM10 is particularly associated with an increased risk of rheumatoid arthritis, while long-term exposure to PM2.5 is associated with an increased risk of chronic rheumatoid arthritis. bombs bombs bombs bombs bombs bombs bombs bombs inflammatory bowel disease and inflammatory bowel disease.

Overall, long-term exposure to industrial pollution and air pollution is associated with an almost 40% higher risk of arthritis, a 20% higher risk of inflammatory bowel disease, and a 15% higher risk of tissue disease.

This is a observational study, and therefore, cannot establish a cause. And the researchers accepted a number of limitations that may have affected their research.

These include: lack of date information detected and onset of autoimmune symptoms; that air quality monitoring may not indicate the presence of air pollution; and that the study may not be widely used because the study participants included high-risk women.

But air pollution has already been linked to an imbalance in the body’s immune system, and smoking, which separates certain toxins along with the excretion of fat, is a stimulant. rheumatoid arthritisthey appear.


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Learn more:
The association between long-term exposure to air pollution and hostile diseases: a community study, RMD Open. DOI: 10.1136 / rmdopen-2021-002055

hint: Long-term exposure to air pollution associated with increased risk of autoimmune diseases (2022, March 15) Retrieved 15 March 2022 from https://medicalxpress.com/news/2022-03-term-exposure-air-pollution-linked .html

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