Linking epigenetic biomarkers to gastrointestinal issues for kids with autism

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As a physician at the University of Missouri Thompson Center for Autism and Neurodevelopmental Disorders, David Beversdorf helps patients with Autism Spectrum Disorder (ASD), many of whom may suffer from gastrointestinal or digestive problems, including constipation with diarrhea. These symptoms of children with ASD get higher than their neurotypical counterparts, although some people may respond well to traditional treatments, such as laxatives.

In a recent study, Beversdorf teamed up with a researcher at Penn State University to identify specific RNA genes associated with gastrointestinal issues in children with autism. The results of the study may help one day create different treatments aimed at reducing the suffering of these people.

Salsa samples were collected from nearly 900 children, some of whom had Autism and had gastrointestinal problems, at several health centers across the country. After examining the samples, the researchers identified specific RNA markers associated with children with Autism and found signs of gastrointestinal disorders.

“We want to understand how a child’s body responds to various viruses that live in the mouth and whether these interactions contribute to gastrointestinal symptoms,” said Steve Hicks, a professor of pediatrics at the College of Medicine. of Penn State, who worked with Beversdorf. on reading. “By identifying these specific microRNAs in the blood of children with Autism, these pathogens may be the next target for enhancing routine treatment or monitoring the therapeutic effect in children with gastrointestinal disorders associated with Autism.”

Beversdorf adds that RNA has regulatory properties in the human body, and the specific RNA identified in the study may have a systemic effect on biological processes related to metabolism, digestion, stress and addiction.

“It’s one of those ‘chicken or egg’ cases where we still don’t know if it is an RNA that can contribute to gastrointestinal events, or if gastrointestinal factors cause the RNA to appear differently. -if, but we have found something. relationship, which will be useful to further explore progress, “said Beversdorf, who also has appointments at the MU College of Technology and Science and the MU School of Medicine. “This research could help contribute to a better treatment one day, where we can follow children with Autism and long-term gastrointestinal symptoms and determine how they can cope with specific treatments, with the ultimate goal. reduce their symptoms and improve them. quality of life. “

“Saliva RNA biomarkers also internal dementia in children with Autism and Autism Spectrum Disorders: Possible Causes of Improved Treatment ”recently published in Frontiers in anthropology.

Increased response to stress associated with gastrointestinal issues in children with autism

Learn more:
David Q. Beversdorf et al, Saliva RNA Biomarkers of Gastrointestinal Dysfunction in Children with Autism and Neurological Disorders: Essential Observations, Frontiers in anthropology (2022). DOI: 10.3389 / fpsyt.2021.824933

hintLinking epigenetic markers to gastrointestinal issues for children with autism (2022, February 25) Retrieved 25 February 2022 from .html

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