Lack of diversity of microorganisms in the gut or elevated gut metabolites implicated in heart failure severity

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Some people who suffer from heart failure have abnormalities in their intestines or have intestinal obstruction, both of which are associated with increased hospital visits and increased risk of death, according to a review of research by the National Institutes of Health. led by Georgetown University. Study of researchers and colleagues.

The internal microbiome it is an ecological system that consists primarily of bacteria and viruses, fungi and protozoa. Microbiome can affect heart disease, which is the leading cause of death in the United States; heart attack, which affects more than six million Americans a year, is usually the end stage of coronary heart disease.

To illustrate, the researchers looked at seven years of biology, medicine and other forms of research from around the world to provide a useful perspective on how the microbiome can influence heart failure. The researchers used a single harmful metabolite, trimethylamine-N-oxide (TMAO), which can be produced by churning the gut microbiota when consuming fatty foods, egg yolks and red meat.

The study appeared June 20, 2022, in Heart Failure Comment.

“For the diagnosis and management of heart disease we rely on some research and test results, but we do not know how heart failure affects gut function, including drinking and diet and medication,” said Kelley Anderson, Ph.D. FNP, CHFN, professor of nursing at Georgetown and author of the study. “There is now an appreciation for the back-to-back relationship between the heart and the intestines, as obviously the heart and vascular system do not function separately – the health of one system can affect the other directly, but clearly The work is still being done scientifically. “

The researchers reported 511 published research articles between 2014 and 2021 that linked the microbiome with heart failure and successfully focused on the 30 most relevant stories. In recent years, more advanced technologies, particularly tools that can effectively analyze the biological functions of DNA and RNA in the body, have provided more detailed information on the relationship between gut / heart and these findings. they were interesting.

Researchers have not been able to determine the effect of food on the interaction between the microbiome and the cardiovascular system due to insufficient data from the studies they studied. The researchers note that nutrition is an important part of cardiovascular health, so being able to identify food effects in relation to the microbiome is an area of ​​interest for future research efforts.

Depending on the possibility of interference to reduce the negative impact of the microbiome on heart diseaseAnderson notes that there are ongoing studies evaluating the use of antibiotics, prebiotics and probiotics, all of which can have an impact on the microbiome, as well as the intestinal mucosa that illuminates and helps eliminate harmful substances from the gut. .

“We are currently conducting further research to evaluate the microbiome in patients with coronary heart disease. We are interested in identifying the symptoms of patients with end-stage heart disease and related diseases. weight loss and wasting time during this stage. cardiovascular diseasesaid Anderson.

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Learn more:
Heart and Gut Relations: A Study of the Microbiome and Trimethylamine-N-Oxide (TMAO) Methods in Heart Disease, Heart Attack Comment (2022). DOI: 10.1007 / s10741-022-10254-6

hintAbnormalities in the intestines or intestinal obstruction associated with severe heart failure (2022, June 20) were recovered 20 June 2022 from diversity-microorganisms-gut – glory.html

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