A Japanese university said Friday in its first clinical trial of this type that it succeeded in transplanting stem cells into a patient with spinal cord injury.
Currently, there is no effective cure for severe paralysis. Spinal cord injury, Japan alone is believed to affect more than 100,000 people.
Surgeons at Keio University in Tokyo want to study whether induced pluripotent stem (iPS) cells can be used to treat damage.
iPS cells are created by stimulating mature, already specialized cells to return to an immature state.
Later, Keio University’s research using iPS-derived cells of the nerve trunk encouraged them to mature into various types of cells.
In the first step of the trial, more than 2 million iPS-derived cells were transplanted into patient cells. Spinal cord With surgery last month.
“This is definitely a big step forward,” Professor Masaya Nakamura of Keio University, who leads the research, told reporters.
But before using the treatment, he added, “there is a lot to do.”
The researchers said the early stages of the study were aimed at confirming the safety of the transplant method.
Patients are monitored by an independent committee for up to 3 months to determine if the study can continue safely and if others can receive a transplant.
The team also wants to see if stem cell implants improve nerve function and quality of life.
The university received government approval in 2019, but due to the Covid-19 pandemic, recruitment was temporarily suspended.
Patient details remain secret, but the team focuses on those injured 14-28 days before surgery.
The number of transplanted cells is determined after safety experiments in animals, and while the researchers are monitoring the therapeutic effect, the main goal of the study is to study the safety of injecting cells. I warned.
© 2022 AFP
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Japan team carries out world-first spinal cord stem cell trial Source link Japan team carries out world-first spinal cord stem cell trial