Interdisciplinary team working to combat antibiotic resistance together

Credit: Leiden University

Immunity is a common problem among patients. The European project of TIPAT trains pharmacologists, biologists and immunologists of six universities in meditation. The ultimate goal is to develop effective treatment guidelines to combat resistance. Coen van Hasselt of LACDR coordinated the project. “By combining all of these researchers with different backgrounds, different questions are asked.”

Fifteen Ph.D. students and their administrators from six European universities work together to understand and prevent them vaccine. Each of his expertise, they work on isolating antibiotics. “This requires a better understanding of the interaction between bacteria, patients and drugs.”

Van Hasselt emphasizes the importance of these different researchers working together. “Microbiology looks at what bacteria do and how they respond to antibiotics, etc. Immunology is about how bacteria work. immune system responds to infection and how you can monitor it in a patient with biological symptoms. And pharmacology speaks to the nature of the drug itself and how it is distributed throughout the body. “

Personal antibiotics and improved treatment guidelines

By combining these three disciplines, Ph.D. students receive different types of training programs. “At TIPAT we are now training young researchers with a background in microbiology, immunology and pharmacology. This allows us to ask different questions in this project. This helps to make rapid progress and produce better results. treatment. “

It is not just about preventing resistance, but also about tackling chronic diseases that today still kill patients often. Van Hasselt explained that it is important to find the right dose for each patient. “At present, patients are often required to be vaccinated at all.

Fighting the resistance of viruses together

Coen van Hasselt, Anh Duc Pham, Wisse van Os, Angie Alarcon Rios, Catharina Meyer. Credit: Leiden University

Internships in different locations

Another aspect of the project is that the Ph.D. students train in threes different conditions: industry training at the company, at the TIPAT academic partner and in the hospital environment. “This gives them a better understanding of how things work in a patient environment or in a pharmaceutical company.”

Visit everywhere

The Ph.D. students and supervisors meet regularly in online meetings. Research teams present their developments and organize online training courses. Twice a year, summer or winter school is organized. “Because of the corona, the previous two were online, but in the summer, all Ph.D. students came to Leiden for the first time, and in the summer we went to Sweden with the whole group.”

But it’s not always just about antibiotics. A business conference was also organized. “When you want to bring a laboratory study to a hospital, it usually means starting a business. These are things that a Ph.D student does not learn during his studies.”

Network for the future

The goal is to continue the training sessions after the project. “We hope it will be the source of something permanent.” In any case, the researchers will find a global network that they can refer to for the rest of their lives. “I want to know that they know each other very well. Not only do they work together, but they also form a real network. They can benefit from this afterwards. That makes this project unique.”

Fighting against bacterial resistance in a smart way

hint: Intermediate groups work to combat viral resistance together (2022, March 25) Retrieved 25 March 2022 from resistance.html

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