Cholesterol levels rise during menopause, and 10% of this increase occurs due to changes in sex hormones. This is a research study published today in European Journal of Cardiovascular Disease Prevention.
Women usually menstruate at the age of 48 to 52, which results in a decrease in isrogen and an increase in hormone-stimulating hormone (FSH). Menopause is thought to cause mata for heart disease since it usually develops after 10 years more than men, and the risk increases after menopause. Previous studies have shown that menstruation is associated with heart disease which increases metabolite levels, but this study is the first one to link this change with changes in female sex hormones. Metabolic changes are partially repaired with them hormone replacement therapy (HRT).
“Habit can not be avoided but it is possible that the negative metabolite changes can be reduced by eating a healthy diet and exercising,” said study author Dr. Eija K. Laakkonen of the University of Jyväskylä, Finland. “Especially for women to control the quality of fat in their diet and get enough exercise to maintain heart health, HRT is another option that women should discuss. providers at this point in their lives. “
The study included 218 women with perimenopause who did not use HRT in the first place. 180 metabolites (lipids, lipoproteins and amino acids) and two hormones (oestradiol and FSH) are derived from blood sample basically and every three to six months until the onset of menopause. The state of menopause was assessed using menstrual cycles and blood FSH levels. The onset of normal death has been described as no more than six months with elevated FSH levels on at least two consecutive occasions. A total of 35 women (15%) started HRT during the study.
Dr. Laakkonen explains: “Our study investigated whether normal hormonal changes altered the metabolite status measured in blood samples taken before and during menstruation. Due to the change in normal conditions, i.e. when the levels “Hormone-modifying hormones and normal imbalances, vary greatly from person to person., the time of diagnosis is individual.”
The researchers conducted a comprehensive statistical analysis to determine what changes occur in metabolite levels during menopause changes and whether these changes are related to changes in sex hormone levels. They also tested whether metabolite conditions differed between HRT users and non-users.
The median age at onset was 51.7 years and the median age was 14 months. Menopause is associated with a significant change in metabolism at the level of 85 metabolites. A recent study showed that hormonal changes of menopause appeared directly to the change in 64 of the 85 metabolites, with an effect size ranging from 2.1% to 11.2%. These include low-density lipoprotein (LDL) cholesterol, triglycerides, fatty acid. same to you amino acid. Statistics were adjusted for age at baseline, duration of follow-up, level of education, smoking status, alcohol use, physical activity, and food quality. Secondary research suggests that HRT is associated with improvement high-density lipoprotein (“good”) cholesterol and a decrease in LDL (“bad”) cholesterol.
Dr. Laakkonen said: “This study links hormonal changes during menstruation to lifestyle changes that improve heart disease. Previous studies have not confirmed the status of menopause without hormone balance, meaning they cannot differentiate the effects of menopause from aging. Our results should be interpreted with caution, since related sex hormones and HRT has been found in research studies and needs to be verified. “
She added: “With regard to HRT, a strong conclusion cannot be reached only based on our observational research since the number of women who started nursing is small and the type of treatment is not controlled. However, our study suggests that start HRT early to menopause, that is, during menopause, it gives the greatest effect on the heart. Women considering HRT should discuss it with their healthcare professional as there are many options and other risk factors such as cancer or stroke history that need to be considered.
Karppinen JE, Törmäkangas T, Kujala UM, da al. Menopause regulates the circulating metabolome: evidence from the following group research, OUP-accepted text, European Journal of Cardiovascular Disease Prevention (2022). DOI: 10.1093 / eurjpc / zwac060
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