Higher blood fats more harmful than first thought 

The image of the microscope shows human muscle cells with a center in blue, the tension resulting from the ceramide stress signal shown in red. Credit: Lee Roberts

A new study has found that an increase in blood pressure in people with type 2 diabetes and obesity is more harmful than previously thought.

In patients with diseases of lifeglory oil levels in the natural blood worry if muscle cells-a response to changes in the cell that damage their structure and function.

Researchers at the University of Leeds found that these were more troubling Cells provide signals that can be sent to other cells.

Signals, also known as ceramides, can have protective effects in the short term, because they are in a mechanism designed to reduce stress in the cell. But in life-threatening illnesses, which have a long-term nature, the signal can kill the organism, make the symptoms worse, and worsen illness.

It has long been known that the amount of fat in the blood to damage tissues and organs, contributes to the development of cardiovascular diseases including type 2 diabetes. kibathe number which has almost tripled worldwide since 1975. In 2016, there were more than 650 million people aged 18 and over who were obese.

Researcher Lee Roberts, Professor of Molecular Physiology and Metabolism at the University of Leeds’s School of Medicine, said: cardiovascular disease. and life-threatening diseases such as diabetes in people with high blood pressure and obesity. ”

In the laboratory, the team imitated blood Oil levels observed in people with life-threatening disease by exposure skeletal muscle Cells to fatty acid called palmitate. Cells begin to transmit ceramide signals.

When these viruses interact with others that have not previously been exposed to fat, the researchers discovered that they communicate with each other, transmitting signals in a pack called extracellular vesicles.

The experiment was repeated in human volunteers with life-threatening diseases and yielded similar results. The findings provide a completely new perspective on how cells respond to stress, with significant results for understanding other life-threatening diseases including obesity.

Professor Roberts said: “This study gives us a new perspective on how stress develops in the cells of obese people, and offers new ways to consider when it comes to producing new ways of treating life-threatening diseases.

“With obesity a disease that continues to increase, the burden of disease-related illnesses such as type 2 diabetes requires new treatments. We hope the results of our study here open up a new field of research to help address this concern. . ”

The paper, entitled “Long-chain ceramides are independent signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle,” was published today Environmental communication.

Abroad research The team includes colleagues from Cambridge University, Bonn University, Bari University, Imperial College and AstraZeneca.

Blood Ceramides-Lipids provide new insights into the link between diet and diabetes and heart disease

Learn more:
Long chain ceramides are independent signaling pathways that link lipotoxicity to stress of the endoplasmic reticulum in skeletal muscle, Environmental communication (2022). DOI: 10.1038 / s41467-022-29363-9

hintHigh blood pressure is more harmful than previously thought (2022, April 1) Retrieved 1 April 2022 from

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