High-intensity focused ultrasound (HIFU) can control prostate cancer with fewer side effects

Behfar Ehdaie says the new treatment is like “male lumpectomy number.” Instead of removing all the tissue in the breast or prostate, doctors have learned that “it is safe and effective to treat specific areas and reduces weight on patients.” Credit: Memorial Sloan Kettering Cancer Center

In recent years, a new treatment technique known as prostate cancer (glandular surgery) has emerged for prostate cancer that is considered a “moderate risk factor” —a majority , small tumors confined to an area of ​​the prostate. At the Memorial Sloan Kettering Cancer Center (MSK), the researchers are working together with an advanced focused therapy system known as high-intensity focused ultrasound (HIFU), guided by Magnetic Resonance Imaging (MRI).

Now a clinical trial has shown this invasive method works well for many patients. The phase 2 trial, conducted by MSK urologic cancer physician Behfar Ehdaie, looked at a type of treatment called HIFU, called MR-guided Focused Ultrasound (MRgFUS), in men suffering from moderate cancer. The new approach to treating the disease effectively in patients also reduces the negative impact of treatment. This shows many men are at risk of middle ground prostate Cancer can be avoided by surgery, chemotherapy, and radiation.

“We believe that this new treatment strategy will improve the lives of many prostate cancer patients,” said Dr. Ehdaie. “To draw exactly how treatment of breast cancer changed 30 years ago, you can think of propaganda as ‘male lumpectomy.’ Instead of removing all the tissue in the breast or prostate, we have learned that it is safe and effective to treat specific areas and reduce weight on patients. “

Results from a clinical trial, published June 14, 2022, in Lancet Oncologyrepresents a major step towards having the new HIFU technique become part of widespread prostate cancer treatment.

When cancer is isolated to the prostate gland, major treatment options include active care (close-up care), surgery, and radiation. But men who need surgery or radiation often have side effects, such as urinary and sexual problems, which can reduce quality of life.

“Advances in prostate cancer over the past two decades have been considered successful for the benefit of all patients, and now caregivers are offering an exciting area that can stimulate injection. in the treatment of prostate cancer, ”said Dr. Ehdaie.

How does the HIFU of prostate cancer work?

MR-guided focused ultrasound (MRgFUS) is an external treatment that takes about two hours. Patients are placed under anesthesia in an MRI machine that covers the lower half of the body. After the device took a picture of the prostate, doctors designed the treatment site and delivered focused ultrasound scans, via MRI. Ultrasound waves emanate from different locations, intervening to attack and kill cells by heating cells to above 158 ° F (70 ° C).

“When you take a picture, you get temperature views to make sure the right places are taken care of,” Dr. Ehdaie said. “The patient has left the anesthesia and returned home. There is no injury or injury to the body for healing. We have shown the system is safe for patients, and they can return to regular activity.”

Prostate cancer HIFU treatment patient success article

John Brannan is one of the winners. In 2016, at the age of 65, his specific prostate antigen (PSA) began to rise significantly. Although prostate cancer is not hereditary, he is terrified because his father, uncle, and two siblings have all died from the disease. A doctor in Boston has recommended surgery to remove the cancer as soon as possible. But that night at a dinner party, John talked to two of his wife’s friends who had undergone prostate cancer surgery and discussed some of the side effects that continue to occur. One friend knew about the clinical trial and connected John with MSK psychiatrist Howard Scher, who referred him to Dr. Ehdaie.

John is eager to sign up. “In addition to my personal reasons for wanting this treatment, I also hope to help future generations who will benefit,” he said. “I have seen the impact of this disease on my family.”

John says the process is simple. Dr. Ehdaie prescribes MRgFUS treatment at the Imaging Center at Memorial Hospital in September 2016. John left several hours later and returned to the hotel with his wife and had dinner. “He came back right away,” he said. “No cutting, no sewing, no lying in a hospital bed for days or weeks, I put on a catheter for the first 24 hours and I was a little tired, but that’s it, the treatment is less painful than biopsies made min. “

Making HIFU for more patients

Dr. Ehdaie says the use of MRgFUS for advanced cancer has been possible due to two major factors in the last 15 years. First, there has been widespread acceptance by experts of the use of intensive monitoring for low-grade drug tumors. The second development is a new imaging technology that allows the insertion of MRI into ultrasound therapy.

In the 2 phase clinical trial, 101 men received new MRgFUS treatment and were treated 6 months and 24 months subsequently. No average- or higher-risk cancer left in the area treated for 88% of patients.

“Perhaps the most important is the harmless,” said Dr. Ehdaie. “None of the men in the study reported urinary incontinence or had bowel problems. Most men are more likely to have erectile dysfunction.”

Based on this information, the FDA in December 2021 approved a technology, called Exablate Prostate, for the treatment of prostate cancer. The FDA also approved the trial that began with the study by Drs. Ehdaie and surgeon Peter Scardino plan to compare MRgFUS propaganda to active care and demonstrate clinical benefits to patients with prostate cancer.

‘New rent in life’

More than five years later, John continues to perform well and avoids surgery and radiation therapy. It has a follow-up-to-follow-the-follow-the-time-the-time-the-time-the-time-the-time biopses in MSK to ensure the disease does not return. He is now 70 years old, lives in Florida with his wife and continues to work by buying and repairing assets.

Since his illness, he has received calls from friends and acquaintances across the country asking how to get them as well. MSK will provide this information remedy to select men and hopes to launch 3 time clinical trials soon.

John says: “I feel like I’ve been given a new lease of life, so I’m trying to make the most of it.” “The use of technology is amazing, and I think it will rise all over the world.”

Ultrasound treatment of prostate cancer with minimal side effects

Learn more:
MRI-Guided Focused Ultrasound (MRgFUS) Focusing Treatment for Medium-Risk Prostate Cancer: Multicenter Study 2b, The Lancet (2022).

hint: High-intensy focused ultrasound (HIFU) can control prostate cancer with side effects (2022, June 15) back 15 June 2022 from -intensity-focused-ultrasound- hifu-prostate.html

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