Flavonoid-rich foods such as berries, apples, pears, and wine appear to have a positive effect on blood pressure levels. This is partly explained by the properties of the gut microbiota. High blood pressure, Journal of the American Heart Association.
“Our gut microbiota plays an important role in metabolizing flavonoids and enhancing cardioprotective effects. This study shows that these hypotensive effects can be achieved by simply changing the daily diet. It provides suggestive evidence, “said Adin Cassidy, Principal Investigator of the Study. PhD and Professor of Nutrition and Preventive Medicine at Queen’s University Global Food Security Institute in Belfast, Northern Ireland.
Flavonoids are compounds naturally found in vegetable foods such as fruits, vegetables, tea, chocolate and wine, and previous studies have shown that they bring various health benefits to the body. Flavonoids are broken down by the body’s gut flora, a bacterium found in the gastrointestinal tract. Recent studies have shown that Gut microbiota, Microbes in the human digestive tract, and Cardiovascular disease (CVD), which is the leading cause of death in the world. Gut microbiota varies widely among individuals, and it has been reported that there are differences in the composition of gut microbiota between people with and without CVD.
As more and more studies suggest that flavonoids may reduce the risk of heart disease, this study evaluated the role of the gut microbiota in the process. Researchers have investigated the association between eating flavonoid-rich foods with blood pressure and the diversity of the gut microbiota. The study also investigated how much variation in the gut flora could explain the association between flavonoid-rich food intake and blood pressure.
A group of 904 adults between the ages of 25 and 82, 57% of men from the German PopGen biobank were recruited for this study. (The PopGen biobank includes participants from a network of seven biobanks in northern Germany.) Researchers evaluated participants. Food intake, Gut microbiota and Blood pressure level Along with other clinical and molecular phenotyping analysis with regular follow-up tests.
The flavonoid-rich food intake of previous year’s participants was calculated from self-reports. food A questionnaire detailing the frequency and intake of 112 foods. Flavonoid levels were assigned to foods according to USDA data on flavonoid content in foods.
Participant’s gut flora was assessed by fecal bacterial DNA extracted from fecal samples. After an overnight fast, participants’ blood pressure levels were measured three times at 3-minute intervals after the first 5-minute rest period. Researchers also collected participant lifestyle information, including gender, age, smoking status, drug use and physical activity, as well as family history of coronary artery disease, daily calories and number of fibers consumed, and each Participant height and weight were measured. Calculate BMI (Body Mass Index).
An analysis of regular flavonoid intake by gut flora and blood pressure levels is as follows:
- Research participants who consumed the most flavonoid-rich foods such as berries, red wine, apples, and pears had lower systolic blood pressure levels and intestinal flora than those who consumed the lowest levels of flavonoids. Highly diverse-rich food.
- Up to 15.2% of the association between flavonoid-rich foods and systolic blood pressure can be explained by the diversity found in the gut flora of participants.
- Eating 1.6 servings of berries per day (1 serving is equivalent to 80 grams or 1 cup) is associated with an average decrease in systolic blood pressure levels of 4.1 mm Hg, with approximately 12% of the association being gut microbiota. Explained by factors.
- Drinking 2.8 glasses of red wine per week (125 ml of wine per glass) reduced systole by an average of 3.7 mmHg. blood Pressure level, 15% of which can be explained by the intestines Microbiota..
“Our findings show that future studies need to examine participants according to their metabolic profile in order to study metabolism and its role more accurately. Gut microbiota In regulating the effects of flavonoids blood pressure“A better understanding of the great individual differences in flavonoid metabolism can fully explain why people who benefit from cardiovascular protection from flavonoid-rich foods outweigh others,” Cassidy said. “.
This study suggests the potential benefits of drinking red wine, but the American Heart Association suggests that if you haven’t already taken alcohol, you shouldn’t start. If you drink, talk to your doctor about the benefits and risks of drinking moderately.according to Dietary Health Statement According to the American Heart Association, alcohol intake should be moderate (1 cup daily for women, 2 cups or less per day for men), and only for non-pregnant women and adults. Becomes a component of a healthy diet. There is no risk to existing health conditions, drug-alcohol interactions, or personal safety and work conditions.
The authors state that the participants in the study were from the general population and were unaware of the hypothesis. However, researchers have a wide range of dietary and lifestyle factors, as residual or unmeasured confounding factors (such as other health conditions and genetics) can lead to bias. The authors pointed out that the focus of this study is on certain flavonoid-rich foods, not all foods and beverages that contain flavonoids.
Co-authors are lead authors Amy Jennings, Ph.D. is. Manja Koch, Ph.D. Dr. Collina Bang; Dr. Andre Franke; and Wolfgang Reeve, MD, M.Sc. The author’s disclosure is included in the manuscript.
Microbial diversity and parabacteroid abundance mediate the link between higher intakes of flavonoid-rich foods and lower blood pressure. High blood pressure (2021). www.ahajournals.org/doi/10.116… TENSION AHA.121.17441
American Heart Association
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