‘Good evidence’ that ADHD drugs might also treat Alzheimer’s disease

A brain scan of a person with Alzheimer’s disease. Credit: Wikipedia / Public Domain.

There is “good evidence” that medications to treat attention deficit hyperactivity disorder (ADHD) can successfully treat the underlying causes of Alzheimer’s disease, has found a comprehensive review of the available data, published online in Journal of Neurology Neurosurgery & Psychiatry.

Clinical trials of noradrenergic drugs, which include antidepressants and medications to treat high blood pressure and ADHD, they now have a guarantee, say the researchers.

Noradrenergic drugs attack the noradrenaline neurotransmitter, also called norepinephrine, which is released by a network of noradrenergic receptors.

This network is important for a lot of excitement ways of understandingincluding attention, learning, memory, work preparation, and the elimination of inappropriate behaviors.

Noradrenergic deficiency occurs early in Alzheimer’s disease and contributes to the perception and neuropsychiatric symptoms that characterize the condition, suggesting that the noradrenergic system would be a good target. drug treatment.

So the researchers asked clinical trials published between 1980 and 2021 used noradrenergic drugs, such as atomoxetine, methylphenidate, and guanfacine, for potential cognitive enhancement and / or neuropsychiatric symptoms in people with neurodegenerative disease.

They included a total of 19 randomized controlled trials focusing on Alzheimer’s disease severe insanitywhich affected 1811 patients: six of these experiments were considered ‘good’, seven as ‘fair’, and six as ‘poor’.

The results of 10 of these tests, which included 1300 patients, were combined for global perception – cognitive / cognitive, memory, speech skills, language and visual acuity.

This demonstrates a small, but significant, effective effect of noradrenergic drugs on general cognition, as measured by the Mental-State Disease Test or the Alzheimer’s Disease Scale Assessment.

Results of 8 clinical trials, involving 425 patients, were then collected for behavioral and neuropsychiatric symptoms, anxiety and depression. And this shows a great positive effect of noradrenergic drugs on depression, even after removing the extract to account for differences in the type of test and the intended results.

“Recovering safe noradrenergic drugs is likely to provide effective treatment in Alzheimer’s disease to fully understand the disorder, ”the researchers said.

They added: “There is a strong reason for additional, clinical trials of noradrenergic in Alzheimer’s disease.”

But many things need to be considered first, they must be done with caution. These include the appropriate intention of patient groups and understanding the bone effects of individual drugs and their interactions with other treatments to reduce the use and maximize the benefits of noradrenergic drugs, they said.

Alzheimer’s disease, not cognitive impairment, causes neuropsychiatric symptoms

Learn more:
Cognitive and neuropsychiatric effects of noradrenergic treatment in Alzheimer’s disease: a systematic review and meta-analysis, Journal of Neurology Neurosurgery & Psychiatry (2022). DOI: 10.1136 / jnnp-2022-329136

hint: ‘Good Evidence’ That ADHD Treatments Can Cure Alzheimer’s (2022, July 5) Retrieved 5 July 2022 from .html

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