Gene variant influences risk for blood clots in COVID patients

Nature Immunology (2022). DOI: 10.1038 / s41590-022-01227-w “width =” 800 “height =” 530 “/>

MBL2 haplotypes predict MBL activity in plasma and thromboembolic disturbances during intensive care. a, MBL functions in haplotype attachments. MBL activity in plasma on day 1 of intensive care was measured by active ELISA using the matrix matrix to capture MBL. Services are defined as the normal part of the NHS. The sex differences shown in Table 1, rows 1-5 resulted in six major haplotypes of MBL2, which are described by their genetic names: HYA, LYA, LXA, HYD, LYB and LYC. HYA, LYA and LXA haplotypes combine to form wild MBL protein and are called ‘A’ haplotypes. HYD, LYB and LYC haplotypes contain error variants referred to as D, B or C alleles, respectively, and are grouped together as ‘0’ haplotypes because they have a general effect on activities MBL. b, Haplotypes classified according to MBL function to upper (HYA / HYA, LYA / LYA, HYA / LYA, HYA / LXA, LYA / LXA), moderate (LXA / LXA, HYA / 0, LYA / 0) and lazy (LXA) / 0, 0/0). MBL performance varied significantly between groups (230% (168-400, intermediate and intermediate) for the large group, 40% (24–70) for the medium group and 0.56% (0.00–1.25) for the group. failed; P Immunology of the weather (2022) DOI: 10.1038 / s41590-022-01227-w

Genetic variation in the natural immune system influences the risk of blood flow in the lungs of patients with severe COVID-19. This was written in a new study published by researchers at Uppsala University and Karolinska Institutet which is now published in Nature of Immunology.

“With this study, we are at a close step to explain why COVID-19 patients are at high risk for relapse. bleeding“said Oskar Eriksson, a physician and researcher at Uppsala University and one of the leading authors of the article.

It appears at the time of the tragedy that patients with COVID-19 had a higher risk of developing anemia, even when treated. bloodthirsty. Why COVID-19 causes such a large activation of the blood coagulation system in some patients is not yet clear. Researchers at Uppsala University and Karolinska Institutet have now found that yes gender differenceswhich regulates the lectin levels of the mannose binding protein in the blood, providing protection against blood clots in the lungs.

Identify coronavirus

Mannose-bound lectin is part of the body’s immune system. It detects and eliminates germs and viruses that are infected by the virus. A recent study (Stravalaci et al. Nature of Immunology Volume 23, pages 275-286 (2022) show that mannose-binding lectin detects SARS-CoV-2 virus that induces COVID-19 and can reactivate infected cells. .

“We can now show how mannose-binding lectin affects COVID-19.’s immune response. ill. with COVID-19. We can indicate that immune system is important for blood formation in patients with COVID-19, something that has long been suspected and may explain why such a high number of blood cells is necessary, “said Oskar Eriksson.

“Large-scale research presented over the past year has identified several genetic variants that contribute to the risk of severe infection from COVID-19. affects patients with COVID-19. ” According to Hugo Zeberg, a physician and researcher at the Karolinska Institute and research partner.

Possibility of blood clotting system in COVID-19 obtained

Learn more:
Michael Hultström et al, The molecular mechanism of action of lectin binding mannose causes thromboembolic disturbances in the significance of COVID-19, Nature of Immunology (2022). DOI: 10.1038 / s41590-022-01227-w

hintGene diversity affects blood flow risk in COVID patients (2022, May 30) returned May 30, 2022 from covid.html

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