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For cancer patients on immunotherapy, harmful gut bacteria might matter more than helpful ones

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Melanoma patients receiving anti-cancer drugs respond to different treatments depending on the type of bacteria in their gut, and new research shows that anti-cancer drugs have more effective than consumers.

The findings were published in collaboration with researchers at Oregon State University, the National Cancer Institute, the Frederick Cancer Center and the University of Pittsburgh. Environmental medicine.

The study is a major breakthrough in the fight against a wide variety of species cancer including melanomathe worst type of skin cancer, says Andrey Morgun of OSU College of Medicine.

“Our research sheds new light on the complex interactions between them internal microbiome and cancer response and pave the way for future studies, ”he said.

Across the country, melanoma is the fifth-most common cancer. Nearly 100,000 new melanoma cases will be diagnosed in the United States next year, and more than 7,000 of these patients are expected to die, according to the American Cancer Society.

One of the most serious cancers, melanoma is killed by metastasizing, or spreading, to other organs such as the liver, lungs and brain.

The new findings include a therapeutic approach called blocking immunization clinics, usually discussed by the early ICB, which changed the treatment of meningitis itself.

ICB far relies on inhibitors that block proteins called test sites produced by others immune system cells-T Cellsfor example — and other cancer cells.

Research sites help prevent the immune response from becoming too strong, but sometimes that means keeping T cells from killing the cancer cells. Thus, when the test sites are blocked, T cells may do their best to kill the cancer cells.

The ICB has been a “game changer” in cancer treatment, Morgun said, and several studies have shown patients ’small intestine plays a role in how a patient responds. The human microbiome Gut is a complex community of more than 10 trillion pathogens representing nearly 1,000 species of bacteria.

Morgun and his collaborators have looked at data from several of my organizations sick melanoma receive a type of ICB known as anti-programmed cell protein, which is reduced to anti-PD-1 drug.

Among other things, they used computer-based, transkingdom network research, developed by Morgun and Natalia Shulzhenko of Carlson College of Veterinary Medicine, Oregon, to determine which viruses are most likely to be involved in the response. better or worse for the solution.

“We have established several microbiotypes and some of them are clearly related to the response to cancer prevention,” Morgun said. “Significance of two subtypes – one heavyweight with the Lachnospiraceae species, and the other heavy with the Streptococcaceae species – are combined with positive and negative clinical responses, respectively.”

The results also show that about a year after treatment the gut microbiota becomes an important factor in responding to regeneration, and that bacteria declining from regeneration play a more important role than those that promote regeneration, he said. .

Princess Dzutsev and Giorgio Trinchieri of the National Cancer Center and Hassane Zarour of the University of Pittsburgh are the authors of the study.


High fiber diets may improve melanoma patients’ responses to immunotherapy


Learn more:
Hassane Zarour, Intestinal microbiota signaling of clinical responses and immunosuppressive factors in melanoma patients treated with anti-PD-1, Environmental medicine (2022). DOI: 10.1038 / s41591-022-01698-2. www.nature.com/articles/s41591-022-01698-2

hintFor cancer patients on immunization, malignant tumors may be more important than donors (2022, February 28) Retrieved 28 February 2022 from https://medicalxpress.com/news/2022-02-cancer-patients -immunotherapy-gut-bacteria .html

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For cancer patients on immunotherapy, harmful gut bacteria might matter more than helpful ones Source link For cancer patients on immunotherapy, harmful gut bacteria might matter more than helpful ones

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