Flu causes cardiac complications by directly infecting the heart

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Researchers have shown for the first time in mice that flu-related heart problems do not cause pneumonia, as has long been predicted.

Instead, Ohio State University research shows, the electrical and pulmonary insufficiency seen in some flu patients is caused by a direct infection of the heart muscle.

The research team found flu-like particles in it Heart cells of infection beraye in the previous work, but it cannot be said that their presence in the heart causes damage to the heart. When researchers infected mice with genetic mutations influenza virus who could not make a copy Heart cellsthe rats received signs of influenza – but no heart complications.

“We have shown that even if you have a severe lung infection, if you use a virus that cannot be repeated in the heart, you will not have heart problems,” said lead author Jacob Yount. scholar professor. of infection and prevention at the Ohio State College of Medicine.

“It proves that direct heart attack is the cause of these problems. Now we need to find out what direct infection does: Does it kill the heart muscle? Does it have long-term effects? There are questions that much to answer. “

The study is published today in the journal Scientific Progress.

It has been established for some time that flu patients in hospitals may develop heart problems. In 2020 apprenticeship found that nearly 12% of adults in the United States hospitalized with the flu over the age of eight experienced sudden, severe heart problems.

Yount studied the flu for years, and his lab developed in mouse model lack of IFITM3, a gene that generates numbers for essential proteins in the primary immune system to eliminate inflammatory diseases. His team got into another 2019 reading that non-IFITM3-infected mice were at greater risk for developing heart disease.

These rats not only are highly susceptible to influenza, but also have one immunosuppressive protein that other people do not have, too: About 20% of Chinese and 4% of Europeans are different. genes that cause IFITM3 deficiency.

“We know these people are more prone to serious infections, and our mouse research will show that they are also more likely to have heart disease and influenza,” said Yount, who is also director of the Viruses and Emerging Pathogens Program. in the program. Ohio State Center for Disease Control.

For this study, the researchers modified the H1N1 virus so that the virus could not steal heart cells to make its own copy. They injected the virus that was transformed into a contagious virus into mice and mice that did not have IFITM3.

Both viruses cause pneumonia and inflammation of the system and cause a large concentration of viruses in mice, but the altered disease is not detected in normal mice cardiac cells and is of low value in in IFITM3 heart failure. These studies allowed direct comparisons between mice with and without myocardial infarction.

The researchers found less damage to the heart muscle, fewer cells to weaken the virus, less scarring, or fibrosis, of the heart tissue and less electrical signal problems in the hearts of mice that received the altered virus.

“We have this type of mouse and this virus that allows us to differentiate between acute pneumonia and the virus directly in the heart. We have not been able to separate these two things in the past,” Yount said. “If you don’t have virus Strong frequency in the heart, you do not see the same electrical shock or the same fibrotic response.

There is still much to be learned. The flu usually focuses on the lungs, but not on the blood or other organs. But it goes into the heart — and finding out how that happens is part of continuing to work in the Yount lab.

Soon it will be mentioned how this study may have an impact on the care of flu patients in the hospital heart problemsbut Yount said these studies suggest that eliminating the infection may be the key to reducing heart problems.

“One thing this shows us is that this is another reason to get flu medicine, because you don’t like yours heart to catch the flu — and possibly, ”he said.

This project has received support from the National Institutes of Health, the Ohio State University Board of Trustees, the Ohio State Center for Disease Control, the Ohio State College of Medicine and the National Academy of Sciences.

Authors include Adam Kenney, Naresh Kumar, Peng Chen, Adrian Eddy, Lizhi Zhang, Ashley Zani, Nahara Vargas-Maldonado, Samuel Speaks, Jeffrey Kawahara, Parker Denz, Lisa Dorn, Federica Accornero, Jianjie Ma, Hua Zhu, Murugesan Rajaram and Chuanxi Cai, all from Ohio State, and Stephanie Aron, Clara Gilbert and Ryan Langlois of the University of Minnesota.

Genetic death associated with influenza-related heart problems

Learn more:
Adam D. Kenney et al, Flu shots in cardiomyocytes cause heart failure and fibrosis, Scientific Progress (2022). DOI: 10.1126 / sciadv.abm5371.

Its formation
Ohio State University

hintInfluenza causes heart attacks by direct heart attack (2022, May 11) retrieved 11 May 2022 from infecting-heart.html

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Flu causes cardiac complications by directly infecting the heart Source link Flu causes cardiac complications by directly infecting the heart

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